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ID 31646
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Author
Kohka, Hideo
Iwagaki, Hiromi
Kobashi, Kenta
Saito, Shinnya
Isozaki, Hiroshi
Takakura, Norihisa
Tanaka, Noriaki
Abstract

Corticoids are well known for their immunosuppressive properties. Interleukin-10 (IL-10) is an intrinsic antiinflammatory peptide in immune diseases, originally identified as cytokine synthesis inhibitory factor. We examined the effect of hydrocortisone sodium succinate (HSS) on the production of IL-10 by human peripheral blood mononuclear cells (PBMCs). PBMCs from healthy volunteers and cancer-burden patients were preincubated separately with or without HSS for 1 h, then stimulated with 5 microg/ml lipopolysaccharide (LPS). Production of IL-10 by human PBMCs was detected with LPS stimulation and its production was higher in cancer-burden patients than in normal volunteers, although this was not statistically significant. HSS suppressed production of IL-10 by LPS-stimulated PBMCs in a dose-dependent manner both in normal volunteers and in cancer-burden patients. These results indicate that, in addition to their antiinflammatory properties, corticoids act to restore the immunosuppressive states even in cancer-burden states

Keywords
steroid
interleukin-10
cancer-burden state
Amo Type
Article
Published Date
1999-02
Publication Title
Acta Medica Okayama
Volume
volume53
Issue
issue1
Publisher
Okayama University Medical School
Start Page
55
End Page
59
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
Web of Sience KeyUT