JaLCDOI 10.18926/AMO/30541
FullText URL fulltext.pdf
Author Araki, Kiyonori| Tsuji, Takao| Onoue, Kimiaki| Tuchiya, Masao| Shinohara, Toru| Inoue, Junichi| Nagashima, Hideo|
Abstract <p>For the detection and characterization of circulating immune complexes (CIC) in various liver diseases, a Clq binding test was used. Though the CIC level was almost normal in HB surface antigen (HBsAg) positive asymptomatic carriers, the level increased in patients with liver diseases. During acute exacerbation of chronic viral hepatitis, the CIC level reached peaks 1 to 3 weeks before and after the hepatic cell necrosis. Study of the sedimentation rates of CIC in various liver diseases showed CIC in the 19s-22s region and in the 7s-19s region. In acid buffer, CIC was dissociated into 5 to 6 components by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). In one case of HBsAg positive severe chronic aggressive hepatitis, CIC was composed of HBsAg, IgG and another three or four undetermined components. During acute exacerbation of chronic hepatitis, minor changes of these dissociation patterns of CIC were observed.</p>
Keywords chronic viral hepatitis circulating immune complexes hepatic cell necrosis HB surface antigen GIq.
Amo Type Brief Note
Published Date 1980-04
Publication Title Acta Medica Okayama
Volume volume34
Issue issue2
Publisher Okayama University Medical School
Start Page 131
End Page 138
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6450515
Web of Science KeyUT A1980JY15600008