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Abe, Yoshiyuki Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine
Fujibayashi, Kazutoshi Medical Technology Innovation Center, Juntendo University
Nishizaki, Yuji Medical Technology Innovation Center, Juntendo University
Yanagisawa, Naotake Medical Technology Innovation Center, Juntendo University
Nojiri, Shuko Clinical Research and Trial Center, Juntendo University Hospital
Nakano, Soichiro Geriatric General Medicine, Juntendo Tokyo Koto Geriatric Medical Center
Tada, Kurisu Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine
Yamaji, Ken Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine
Tamura, Naoto Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine
Abstract
Pneumocystis pneumonia (PCP) due to Pneumocystis jirovecii infection is the leading cause of fatal opportunistic infections in immunocompromised patients. We will determine whether a daily sulfamethoxazole-trimethoprim (SMX/TMP) dose of 200/40 mg was non-inferior to 400/80 mg for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy. This is a randomized, open-label, multicenter controlled trial. The primary outcome is the rate of PCP prevention at 52 weeks. The secondary outcome is the discontinuation rate of SMX/TMP. The trial will evaluate the optimal dose of SMX/TMP for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy.
Keywords
pneumocystis pneumonia
prophylaxis
systemic rheumatic disease
sulfamethoxazole-trimethoprim
conventional-dose versus half-dose
Amo Type
Clinical Study Protocol
Published Date
2019-02
Publication Title
Acta Medica Okayama
Volume
volume73
Issue
issue1
Publisher
Okayama University Medical School
Start Page
85
End Page
89
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2019 by Okayama University Medical School
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publisher
Refereed
True
PubMed ID