JaLCDOI 10.18926/AMO/30306
FullText URL fulltext.pdf
Author Tsutsumi, Koji| Nishibori, Masahiro| Saeki, Kiyomi|
Abstract <p>In the presence of extracellular Ca2+, 6,7-dihydro-6,8,8, 10-tetramethyl-8H-pyrano [3, 2-g] chromone-2-carboxylic acid (EAA) had an inhibitory effect on the substance P-induced histamine release from rat peritoneal mast cells. Not only Ca2+ but also Mg2+, Sr2+ and Ba2+ were effective in enhancing the activity of EAA. Marked tachyphylaxis to EAA developed irrespective of the presence or absence of extracellular Ca2+. Cross-tachyphylaxis was observed between EAA and disodium cromoglycate (DSCG). These results indicate that the mode of action of EAA is similar, but not identical, with that of DSCG.</p>
Keywords 6 7-dihydro-6 8 8 10-tetramethyl-8H-pyrano(3 2-g) chromone-2-carboxylic acid (EAA) disodium cromoglycate histamine release alkaline-earth metal ions substance P
Amo Type Article
Published Date 1984-08
Publication Title Acta Medica Okayama
Volume volume38
Issue issue4
Publisher Okayama University Medical School
Start Page 367
End Page 374
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6208753
Web of Science KeyUT A1984TG25900006