JaLCDOI 10.18926/AMO/41322
FullText URL 64_6_367.pdf
Author Tantular, Indah S.| Matsuoka, Hiroyuki| Kasahara, Yuichi| Pusarawati, Suhintam| Kanbe, Toshio| Tuda, Josef S. B.| Kido, Yasutoshi| Dachlan, Yoes P.| Kawamoto, Fumihiko|
Abstract We conducted a field survey of glucose-6-phosphate dehydrogenese (G6PD) deficiency in the eastern Indonesian islands, and analyzed G6PD variants molecularly. The incidence of G6PD deficiency in 5 ethnic groups (Manggarai, Bajawa, Nage-Keo, Larantuka, and Palue) on the Flores and Palue Islands was lower than that of another native group, Sikka, or a nonnative group, Riung. Molecular analysis of G6PD variants indicated that 19 cases in Sikka had a frequency distribution of G6PD variants similar to those in our previous studies, while 8 cases in Riung had a different frequency distribution of G6PD variants. On the other hand, from field surveys in another 8 ethnic groups (Timorese, Sumbanese, Savunese, Kendari, Buton, Muna, Minahasa, and Sangirese) on the islands of West Timor, Sumba, Sulawesi, Muna and Bangka, a total of 49 deficient cases were detected. Thirty-nine of these 49 cases had G6PD Vanua Lava (383T>C) of Melanesian origin. In our previous studies, many cases of G6PD Vanua Lava were found on other eastern Indonesian islands. Taken together, these findings may indicate that G6PD Vanua Lava is the most common variant in eastern Indonesian populations, except for Sikka.
Keywords Glucose-6-phosphate dehydrogenase deficiency rapid G6PD test eastern Indonesian population molecular analysis G6PD Vanua Lava
Amo Type Original Article
Published Date 2010-12
Publication Title Acta Medica Okayama
Volume volume64
Issue issue6
Publisher Okayama University Medical School
Start Page 367
End Page 373
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21173806
Web of Science KeyUT 000285664200003