JaLCDOI 10.18926/AMO/32728
FullText URL fulltext.pdf
Author Murao, Tsuyoshi| Ohmori, Hiroyuki| Sonobe, Hiroshi| Matsuo, Keisuke| Tsutsumi, Akira| Ogawa, Katsuo|
Abstract <p>Oncogenesis of human adenovirus type 12 in the brain of rats was examined. Newborn rats of Sprague-Dawley and Donryu&#12288;strains were injected intracranially with human adenovirus type 12.&#12288;The incidence of intracranial tumors was 91% (30/33) in SpragueDawley&#12288;and 56% (14/25) in Donryu rats. Except for one tumor nodule&#12288;located in the parietal cortex of a Sprague.Dawley rat, all tumors&#12288;developed in the paraventricular areas or in the meninges. Tumors were quite similar histologically to those induced in hamsters and&#12288;mice resembling the undifferentiated human brain tumors such as medulloblastoma,&#12288;ependymoblastoma and embryonic gliomas. From&#12288;the histological features and primary sites of tumor development, it is&#12288;suggested that the tumors in the brain of rats induced by adenovirus type 12 originate from the embryonic cells in the&#12288;paraventricular area&#12288;and also from the undifferentiated supporting cells of the peripheral&#12288;nerves in the&#12288;leptomeninges.</p>
Amo Type Article
Published Date 1974-02
Publication Title Acta Medica Okayama
Volume volume28
Issue issue1
Publisher Okayama University Medical School
Start Page 47
End Page 58
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 4275715
Author Hamazaki, Yukio| Ogawa, Katsuo| Tsutsumi, Akira| Ohmori, Masaki| Taguchi, Kohji|
Published Date 1963-02
Publication Title Acta Medicinae Okayama
Volume volume17
Issue issue1
Content Type Journal Article