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ID 31041
JaLCDOI
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Author
Tanaka, Kotaro
Sakagami, Kenichi
Orita, Kunzo
Abstract

It is now well recognized that pre-transplant donor-specific blood transfusion (DST) has a beneficial effect on the survival of allografts. To determine the optimal interval between DST and transplantation, and to analyze the mechanisms of this effect, the survival of cardiac allografts to rats which received a single DST was examined. The cardiac allograft survival was found to be prolonged when the DST was performed 1 to 6 weeks before grafting. In addition, recipient rat sera collected 1 to 6 weeks after a single DST showed significant inhibition of a mixed lymphocyte reaction (MLR). This MLR inhibition correlated with prolongation of survival of histoincompatible rat cardiac allografts. It thus appears that a single DST given from 1 to 6 weeks before transplantation has a beneficial effect on allograft survival and that MLR inhibition may be essential for inducing the effect of transfusion on organ transplantation.

Keywords
donor-specific blood transfusion
cardiac allograftingm
mixed lymphocyte reaction
Amo Type
Article
Published Date
1988-02
Publication Title
Acta Medica Okayama
Volume
volume42
Issue
issue1
Publisher
Okayama University Medical School
Start Page
31
End Page
36
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT