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ID 17068
Eprint ID
17068
FullText URL
Thumnail 92_629.pdf 228 KB
Title Alternative
Inverse relationship between heart rate and myocardial oxygen consumption per beat
Author
Haraoka, Shoichi
Saito, Daiji
Ihoriya, Kazuo
Nagahana, Haruki
Fujii, Akinobu
Mashima, Ikuzo
Abstract
Relationship between heart rate and myocardial oxygen consumption per beat was studied in anesthetized open-chest dogs. Myocardial oxygen consumption per minute (MVO(2)) was calculated as the product of the left coronary artery blood flow and coronary arterio-venous oxygen difference. Myocardial oxygen consumption per beat (MVO(2)-Beat) was the quotient of MVO(2) divided by heart rate (HR). HR was varied in 78-210 beats/min with left atrial pacing. Systemic arterial and left ventricular enddiastolic pressure were kept constant, and arterial blood gases were within physiological ranges. Although MVO(2) correlated significantly with HR (r=0.71), MVO(2)-Beat decreased in association with an increase in heart rate. Closer relationship was observed between MVO(2)-Beat and HR; MVO(2)-Beat (ml/100g LV muscle)= -0.00036 + 0.13, r= -0.86, P<0.001. As the results, MVO(2) was represented as a quadratic equation of HR; MVO(2) (ml/min/100g LV muscle)= -0.00036HR(2) + 0.13HR. There was a good correlation (r=0.88) between MVO(2)-Beat and the area under a stroke left ventricular pressure curve. This finding and constant systemic arterial and left ventricular pressure suggest that the inverse relationship between MVO(2)-Beat and HR is mainly due to a reduction in duration of systolic left ventricular wall tension.
Keywords
心拍数
心筋酸素消費量
左室内圧
収縮時間
Published Date
1980-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume92
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
629
End Page
633
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/92/5-6/92_5-6_629/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma