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ID 13780
Eprint ID
13780
FullText URL
Thumnail 106_789.pdf 1.27 MB
Title Alternative
Human T-lymphotropic virus type-Ⅰinfection and pulmonary fibrosing changes in patients with lung cancer
Author
Nanba, Seiji
Abstract
Thirty-one patients with lung cancer in Okinawa known as HTLV-Ⅰendemic area, and 140 patients in Okayama were evaluated in regard to HTLV-Ⅰinfection and iterstitial pulmonary shadows. The presence of HTLV-Ⅰinfection was examined by the polymerase chain reaction (PCR) method in peripheral blood mononuclear cells, and indirect immunofluorescent (IF) assay in sera. Interstitial pulmonary shadows on the chest roentgenograph, were classified according to the grade of fibrosis. The rate of HTLV-Ⅰinfection in patients with lung cancer was higher than that in healthy controls by IF assay in both districts. The rate of anti-HTLV-Ⅰantibody was higher in lung cancer patients with severe fibrosis than in those with milder fibrosis, but the grade of fibrosis and existence of pX gene had no relation in Okinawa or in Okayama. The incidence of patients with anti-HTLV-Ⅰantibody was higher in patients with adenocarcinoma and squamous cell carcinoma than in those with small cell carcinoma. These findings suggested that HTLV-Ⅰinfection was closely involved in some patients with non-small cell lung cancer having intersitital pulmonary shadows.
Keywords
肺癌
びまん性間質性肺病変
polymerase chain reaction
間接蛍光抗体法
HTLV-Ⅰ
Note
原著
Published Date
1994-08
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume106
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
789
End Page
798
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/106/7-8/106_7-8_789/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma