このエントリーをはてなブックマークに追加
ID 31587
JaLCDOI
FullText URL
Author
Kitani, Hikaru
Kajimoto, Kazuhiro
Sugimoto, Keisuke
Mifune, Takashi
Yokota, Satoshi
Hiramatsu, Junichi
Kawaraya, Masashi
Tanizaki, Yoshiro
Abstract

Immunoallergological studies were carried out to clarify the differences between 24 patients with drug-induced asthma (DIA) and 240 with non-drug-induced asthma (non-DIA). The mean values of age, skin reaction to Candida albicans (C. albicans), serum IgE levels, specific IgE antibodies to house dust (HD) and C. albicans, bronchial sensitivity and leukotriene B4 (LTB4) synthesis from peripheral venous blood in patients with DIA were not significantly different from those in patients with non-DIA. In contrast, the frequency of positive skin reaction to HD and histamine release from peripheral basophils by anti-IgE were significantly lower in DIA than in non-DIA. These results agree with the reports that DIA was often observed in non-atopic asthma. But, the mean value of serum IgE was very high in DIA as well as in non-DIA. This result suggests that IgE mediated reaction in DIA is important. Furthermore, the proportion of neutrophils in bronchoalveolar lavage fluid (BALF) was significantly lower in DIA than in non-DIA. Our findings suggest that a decrease of intrapulmonary neutrophils might play an important role in the pathophysiology of DIA.

Keywords
drug allergy
aspirin-induced asthma. LgE-mediated reacion
chemical mediator
bronchoalveolar lavage
Amo Type
Article
Published Date
1993-10
Publication Title
Acta Medica Okayama
Volume
volume47
Issue
issue5
Publisher
Okayama University Medical School
Start Page
317
End Page
321
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT