JaLCDOI 10.18926/AMO/31904
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Author Motokura, Kiyoshi| Tani, Kazuyoshi| Ugaki, Masaaki| Sato, Shiro| Takata, Choji| Naito, Takakazu| Nabeshima, Saburo| Yamasaki, Ryohei| Yamamoto, Michio| Nishishita, Soichi| Nobuki, Shigeo| Tanimoto, Junichi| Kojima, Sumikazu| Shiaku, Midori| Iguchi, Yoshiko|
Abstract <p>With the purpose of revealing the biological effects of the X-ray irradiation the authors extracted phospholipids from the liver of irradiated animals and proved that this substance has the action to inhibit the growth of the bone marrow cells, the motility of pseudo-eosinophilis and the erythropoiesis in tissue culture, suggesting that the injury will mainly be induced by the toxic substances produced by irradiation.</p>
Amo Type Article
Published Date 1960-04
Publication Title Acta Medicinae Okayama
Volume volume14
Issue issue1
Publisher Okayama University Medical School
Start Page 46
End Page 54
NCID AA00041342
Content Type Journal Article
language 英語
File Version publisher
Refereed True
NAID 120002312680
JaLCDOI 10.18926/AMO/31898
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Author Yamamoto, Michio| Tanimoto, Junichi| Kojima, Sumikazu| Nobuki, Shigeo| Hagitani, Akira| Iguchi, Yoshiko| Akagi, Eiko| Ofuji, Tadashi| Asaka, Takakazu| Kamura, Junta| Shibata, Tsuneo|
Abstract <p>The unsaturated fatty acid fraction extracted from the liver of rabbit irradiated with X-rays exerts a strong cytotoxic effect on human coelothelioma cells and Yoshida sarcoma cells both in vitro and in vivo. The cell damage seems to initiate at the nucleus, finally leading to the complete cytolysis. The inhibiting effect of this substance on the mitosis of Yoshida sarcoma cells can be observed, especially marked from prophase up to metaphase giving almost the same results obtained after X-ray irradiation. From these results and the observations reported by several authors on the cell damage by X-ray irradiation, weshould call special attention to the fact that the essential mechanism of X-ray irradiation can be attributed to the cell toxin produced after the irradiation.</p>
Amo Type Article
Published Date 1960-04
Publication Title Acta Medicinae Okayama
Volume volume14
Issue issue1
Publisher Okayama University Medical School
Start Page 55
End Page 67
NCID AA00041342
Content Type Journal Article
language 英語
File Version publisher
Refereed True
NAID 120002313084