JaLCDOI 10.18926/AMO/32836
FullText URL fulltext.pdf
Author Gomita, Yutaka| Ichimaru, Yasuyuki| Moriyama, Minehiro| Araki, Hiroaki| Futagami, Koujiro|
Abstract <p>In considering the characteristics of the action of anxiolytic drugs and their mechanism in the brain, it may be necessary not only to study the behavioral pharmacology but also to perform brain site research. In the present study, the action of anxiolytic drugs was examined with respect to various behaviors that were induced by stimulating the brain areas related to emotions such as reward (pleasure) or aversion in rats. First, the low rate of response in lateral hypothalamic self-stimulation behavior was induced by schedules of low current brain stimulation, variable interval (VI) and differential reinforcement of low rate (DRL). Anxiolytic drugs such as benzodiazepines facilitated these low-rate responses. The drug susceptibility was highest in the low current stimulation, lower in the VI stimulation, and lowest in the DRL stimulation schedules. Furthermore, it was found by the auto-titration method in intracranial self-stimulation behavior that anxiolytic drugs decreased the threshold of stimulation reward. Second, it was recognized using the decremental lever pressing (DLP) paradigm that anxiolytic drugs increased the threshold of aversive stimulation of mesencephalic dorsal central gray (DCG), and this increasing effect of the drug was antagonized by GABA receptor blockers such as biccuculline. Finally, it was examined whether or not the conflict situation is established by combining brain stimulation reward and aversion, such as foot-shock or DCG stimulation. As a result, the conflict behavior was established by combining not only the brain stimulation reward and foot-shock aversion, but also the brain stimulation reward and DCG stimulation aversion. Further anxiolytic drugs exhibited anti-conflict action in both situations. The susceptibility of anxiolytic drugs was higher with respect to the conflict behavior induced by intracranial reward and aversion than to that induced by the conventional method based on milk reward and foot-shock aversion. These results suggest that behavioral methods using brain stimulation can examine the mechanisms of direct drug action at the brain stimulation site. Indeed, in the present brain stimulation behavioral study, anxiolytic drugs such as benzodiazepines increased the stimulation threshold in lateral hypothalamic self-stimulation and inhibited the DCG aversive stimulation, thus resulting in an anticonflict action of the drugs.</p>
Keywords anxiolytic drugs lateral hypothalamic self-stimulation escape behavior induced by mesencephalic dorsal central gray stimulation conflict behavior rats
Amo Type Review
Published Date 2003-06
Publication Title Acta Medica Okayama
Volume volume57
Issue issue3
Publisher Okayama University Medical School
Start Page 95
End Page 108
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 12908007
Web of Sience KeyUT 000183816500001
JaLCDOI 10.18926/AMO/31736
FullText URL fulltext.pdf
Author Gomita, Yutaka| Ichimaru, Yasuyuki| Ohizumi, Norihide| Yamada, Hirotoshi| Moriyama, Mimehiro| Araki, Yasunori|
Abstract <p>The anti-ulcer action of clotiazepam (a thienodiazepine derivative) was studied in mice subjected to non-physical and physical stimuli in a communication box. There were two groups of mice: the &#34;sender&#34; mice that received electric shocks on the feet and responded by squealing and jumping, and the &#34;responder&#34; mice that were affected by the senders' responses without receiving shocks on the feet. Gastric ulcers resulted in both groups. The effect of clotiazepam was compared with that of diazepam. The incidence of gastric ulcers was suppressed by clotiazepam at a dose of 3 mg/kg, per os, in &#34;responder&#34; and &#34;sender&#34; mice, and by diazepam at a dose of 1 mg/kg, per os, in &#34;responder&#34; mice. These results suggest that clotiazepam has a suppressive action against gastric ulcers produced by non-physical or physical stimuli, although its potency is slightly weaker than that of diazepam.</p>
Keywords gastric ulcer clotiazepam non-physical and physical stimuli mice
Amo Type Article
Published Date 1987-12
Publication Title Acta Medica Okayama
Volume volume41
Issue issue6
Publisher Okayama University Medical School
Start Page 275
End Page 278
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2894110
Web of Sience KeyUT A1987L530300006
JaLCDOI 10.18926/AMO/30469
FullText URL fulltext.pdf
Author Ichimaru, Yasuyuki| Gomita, Yutaka| Araki, Yasunori| Moriyama, Minehiro|
Abstract <p>Effects of HR-592, a new derivative of indole, on conditioned avoidance and intracranial self-stimulation behavior were investigated in rats using a shuttle box and a Skinner box, respectively. The oral administration of HR-592 at doses of 3-10 mg/kg caused a dose-dependent suppression of the conditioned avoidance response. Even the escape response was slightly suppressed in the group administered 10 mg/kg of HR-592. The self-stimulation behavior was suppressed dose-dependently from 1 to 8 h after the administration of 6-10 mg/kg of HR-592. These results indicate that the action of HR-592 on conditioned avoidance response and intracranial self-stimulation behavior is similar to the action of neuroleptics.</p>
Keywords HR-592 indole derivative avoidance hypothalamic self-stimulation rats
Amo Type Article
Published Date 1990-02
Publication Title Acta Medica Okayama
Volume volume44
Issue issue1
Publisher Okayama University Medical School
Start Page 35
End Page 39
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2330844
Web of Sience KeyUT A1990CT06800005