JaLCDOI 10.18926/AMO/31526
FullText URL fulltext.pdf
Author Shimamura, Junnosuke| Taketa, Kazuhisa| Ide, Takero| Nakata, Kenichi| Nagashima, Hideo|
Abstract <p>Levels of plasma cyclic AMP, serum immunoreactive insulin (IRI), serum c-peptide immunoreactivity (CPR) and blood sugar (BS) were determined 0, 15, 30, 45 and 60 min after a glucagon injection (0.01 mg per kg body weight) in normal controls, patients with acute hepatitis and liver cirrhosis. Plasma cyclic AMP responses to glucagon in liver disease patients varied widely in peak value, and only in patients with fulminant hepatitis and decompensated liver cirrhosis with poor prognosis was the response suppressed. The peak response of BS was found significantly later in liver cirrhosis patients than in normal controls. IRI and CPR responses to glucagon were lower in acute hepatitis patients than in normal controls and liver cirrhosis patients. IRI levels and their sum were also lower in acute hepatitis patients, although CPR levels were not significantly different. Thus, the ratio of the sum of CPR from 0 to 60 min to that of IRI was significantly higher in acute hepatitis, indicating impaired pancreatic secretion of insulin to glucagon stimulation as well as increased uptake of insulin by the liver in acute hepatitis.</p>
Keywords liver diseases glucagon cyclic AMP immunoreactive insulin c-peptide immunoreactivity
Amo Type Article
Published Date 1985-10
Publication Title Acta Medica Okayama
Volume volume39
Issue issue5
Publisher Okayama University Medical School
Start Page 385
End Page 396
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3000142
Web of Sience KeyUT A1985ATK7300005
JaLCDOI 10.18926/AMO/30548
FullText URL fulltext.pdf
Author Ide, Takero| Taketa, Kazuhisa| Watanabe, Makoto| Ikeda, Satoru| Izumi, Masaki| Sokabe, Teruko| Kono, Hiroshi| Yamamoto, Yoshio|
Abstract <p>&lt;p&gt;The levels of HDL-cholesterol and gamma-glutamyltransferase in the sera of 17 patients with alcoholic liver injury were followed after abstinence and compared with those of 11 patients with acute non-alcoholic hepatitis. The activity of gamma-glutamyltransferase decreased in all cases irrespective of the type of liver injuries. The level of HDL-cholesterol also decreased in 11 of 17 cases with alcoholic liver injury. The other alcoholics, in whom HDL-cholesterol level increased or showed no definite change after withdrawal of alcohol, had severe and advanced liver injuries. In non-alcoholic hepatitis, the HDL-cholesterol level increased as normal liver functions were restored except for one case with cholestatic features. It was concluded that alcohol intake can increase HDL-cholesterol level even in the presence of a concomitantly induced hepatic lesion.&lt;/p&gt;</p>
Keywords alcoholic liver injury HDL-cholesterol ?-glutamy1-transferase.
Amo Type Article
Published Date 1980-11
Publication Title Acta Medica Okayama
Volume volume34
Issue issue5
Publisher Okayama University Medical School
Start Page 293
End Page 299
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6108050
Web of Science KeyUT A1980KT96800001