岡山医学会 Acta Medica Okayama 0030-1558 66 10 1954 皮膚科領域におけるVitamin B(1)の研究 第1編 皮膚疾患における血中総B(1)量について 2111 2123 EN Taisuke Ichiyama The blood level of Vitamin B(1) in 80 cases of various dermatologic disorders was defermined with thiochrome method using permutit and considering the value of the healthy individuals and the results of other investigators, the minimum limit was established on 6.0γ% and the following results were obtained: 1) In 17 cases of healthy individuals, the average of the blood level of total Vit. B(1) was 8.34γ%, and it presented lower value in summer rather compared with in autumm. The average of the blood level of Vit. B(1) in dermatologic disorders was 6.51γ%, i.e., 1.83γ% lower than in the healthy individuals. 2) Concerning eczema acutum, it showed normal value in erythematous and desquamatous stadium. but in the rest of the stadium most of them showed lower value, in eczema chronicum it also showed lower value in cases in which the course was prolonged. 3) In dermatitis acuta and Duhring's dermatitis, the blood level of Vit. B(1) decreased in cases in which excessive exsudation could be seen, pemphigus, Domian enanthem and pellagra showed obvious deficiency of Vit. B(1). Moreover, in most of the cases of erythematodes and psoriasis vulgaris showed Vit. B(1) deficiency, but in acne vulgaris, alopecia arezta, chloasma and erythema induratum Bazin showed normal value. 4) Vit. B(1) takes part in the metabolism with close relation with the functions of many organs, as well as with other Vitamins and endocrine system; so the variation of the blood level of Vit. B(1) might not be attributed as the only cause of the previous diseases, but it could be concluded that in some of the cases, the deficiency of Vit. B(1) takes an important roll in the cause or degeneration of dermatologic diseases. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 10 1954 皮膚科領域におけるVitamin B(1)の研究 第2編 皮膚疾患における血中総B(1)量と肝機能との関係について 2125 2138 EN Taisuke Ichiyama According to the fact that the Synthesis of Co-carboxylase from Vit. B(1) takes place in the liver, and in the case of Vit. B(1) deficiency the insufficiency of the liver function could often be observed, therefore. the close relation between Vit. B(1) and liver function could be presumed. I have examined the relation between Vit. B(1) and liver function in 71 cases of various dermatologic diseases, according to Takata's reaction, hepatosulphalein method and urobilinogen reaction in urine, as the examination of liver function and obtained the following results. 1) 55.6% of the cases in which the blood level of Vit. B(1) was below 6.0γ% showed liver dysfunction, especially the allergic diseases such as eczema, urticaria and prurigo tended to liver dysfunction, and the similar tendency could also be seen in Duhring's dermatitis, pemphigus and pellagra. 2) 66.7% of the cases in which the blood level of Vit. B(1) was above 6.0γ% showed normal liver function, and chloasma, alopecia areata, verrucae planae juveniles and trichophytia showed normal function. 3) In acne vulgaris, erythema induratum Bazin, erythematodes and psoriasis vulgaris no definite relation between Vit. B(1) and liver function could be observed. 4) Including allergic dermatoses, in the dermatologic diseases which tend to exsudation, both positive urobilinogen reaction and deficiency of Vit. B(1) could be observed in many cases. 5) Among the 3 reactions for the examination of liver function, the hepatosulphalein method concured closely with blood level of Vit. B(1). 6) Approximately 90% of the cases had both normal liver function and normal Vit. B(1) value, and 90% with liver dysfunction and deficiency of Vit. B(1). Etiology of many skin diseases are still unknown, and in the relation of Vit. B(1) deficiency and the liver dysfunction to the cause of various dermatologic disorders, the cause and the result are also not clear, but according to my experiments it could be said that the Vit. B(1) deficiency and the liver dysfunction play an impostant roll in the cause and course of some dermatologic disorders. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 10 1954 皮膚科領域におけるVitamin B(1)の研究 第3編 皮膚疾患における血中総B(1)量と尿沢田氏反応との関係 2139 2156 EN Taisuke Ichiyama Sawada's urinary pyruvic acid reaction, which is known as indirect diagnostic method of Vit. B(1) deficiency, is widely applicated in various medical disorders, but in my researches in dermatologic area I could not find of this reaction. By applicating Sawada's reaction in dermatodes, following results were obtained: 1) In 66 cases of 115 patients, this reaction appeared positive (57.4%) i. e., about 20% higher than normal persons (36.0%). Showing positivity in main diseases. In eczema chronicum 75%, dermatitis acuta 71.4%, ephelides 60.0%, chloasma 57.4%, urticaria and erythema induratum Bazin 50.0% each. alopecia areata 42.8%, acne vulgaris 37.5%, appeared positive. while in psoriasis vulgaris and trichophytia only 25.0% appeared positive. 2) As liver function tests, Takata's reaction, Hepatosulphalein method and urobilinogen reaction in urine were taken and in most of the cases in which Sawada's reaction appeared negative, these 3 reactions were also negative, but when Sawada's reaction appeared positive, these 3 reactions appeared positive only in a few case. therefore the deficiency of liver function can not be presumed from the positive appearance of this reaction. Determining the liver function from the previous 3 reactions, in the relation between the liver function and Sawada's reaction, 80.0% of the cases with liver dysfunction showed positive reaction of this test. 3) Determining the relation between the blood level of Vit. B(1) and Sawada's reaction, the average of the blood level of Vit. B(1) in the negative cases of this reaction was 7.49γ%. and that of the positive cases was 5.57γ%, and definite difference between them could be observed. Classifying the results of the blood level of Vit. B(1) in two groups, i.e., below 6.0γ% as deficiency and above 6.0γ% as normal value, in the normal cases 58.33% appeared negative in Sawada's reaction, therefore it could not be conclunded that in the cases which the blood level of Vit. B(1) appears normal, Sawada's reaction appears negative. 4) 82.35% of the cases in which Sawada's reaction appeared negative, showed normal blood level of Vit. B(1), while only in the half of the positive cases I found this level below 6.0γ%. So when we apply this reaction in clinical examination, it is misleading to determine Vit. B(1) deficiency by the positive appearance of this reaction. No potential conflict of interest relevant to this article was reported.