JaLCDOI 10.18926/AMO/31900
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Author Oda, Nobuo| Ida, Noriaki|
Abstract <p>1) The influence of thyroid secretion upon the induction of leukemia in Dba/2 male mice by methylcholanthrene was investigated. Radiothyroidectomy significantly reduced the incidence of leukemia in these mice. This reduction in incidence did not occur if radiothyroidectomy was performed after the administration of the carcinogen. 2) Data indicated that hypothyroidism following radiothyroidectomy interfered with the initiation rather than the promotion of methylcholanthrene- induced-Ieukemogenesis. 3) No correlation between incidence of leukemia and body weights in the mice was noted.</p>
Amo Type Article
Published Date 1960-04
Publication Title Acta Medicinae Okayama
Volume volume14
Issue issue1
Publisher Okayama University Medical School
Start Page 14
End Page 21
NCID AA00041342
Content Type Journal Article
language 英語
File Version publisher
Refereed True
NAID 120002312534
JaLCDOI 10.18926/AMO/32371
FullText URL fulltext.pdf
Author Ida, Noriaki| Oda, Nobuo| Yoda, Tadao| Kiyama, Takashi|
Abstract <p>1. The objective of this investigation was to test the influence of mammary cancer tissue extract on the induction of various tumors by urethan. Three strains of female mice, Balb/c, Zb and Db, were used in this experiment. 2. It was found that urethan was a multipotential carcinogen in the induction of (a) lung tumor, ovarian hemorrhagic cyst, and hemorrhagic lesions in various tissue in Balb/c mice, (b) lung tumor, hepatoma, leukemia, mammary cancer, Harderian gland tumor and hemorrhagic lesions in various tissues such as spleen, mesenteric lymphnode, liver and ovary in Zb strain, and (c) lung tumor, mediastinal lymphoma, leukemia, hepatoma and hemorrhagic lesions in the liver and ovary in Db mice. 3. Mammary cancer tissue extract seemed to have a promotive effect on the generalization of the mediastinal lymphoma induced by urethan in Db female mice.</p>
Amo Type Article
Published Date 1962-10
Publication Title Acta Medicinae Okayama
Volume volume16
Issue issue5
Publisher Okayama University Medical School
Start Page 253
End Page 264
NCID AA00041342
Content Type Journal Article
language 英語
File Version publisher
Refereed True
NAID 120002312307