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ID 31117
JaLCDOI
FullText URL
Author
Jin, Li
Murakami, Tetuhide H
Janjua, Najma a
Hori, Yasuo
Abstract

The purpose of this study was to investigate the effects of topical treatment with zinc oxide (2.5%, 10%, 25% and 50%) and intraperitoneal treatment with diethyldithiocarbamate (DEDTC) (50 mg/kg, 500 mg/kg and 1,000 mg/kg) on the mitotic index of epidermal basal cells in incised and non-incised mouse skin. The present results showed that topical application of zinc oxide (25% and 50%) increased the mitotic index of epidermal basal cells in incised skin and non-incised skin. Conversely, intraperitoneal administration of DEDTC (500 mg/kg and 1,000 mg/kg) decreased the mitotic index, but only in the incised skin. These results suggest that mitosis of epidermal basal cells may be stimulated by the topical application of zinc oxide both in incised and non-incised mouse skin, and that it also may be inhibited by the intraperitoneal administration of DEDTC in incised mouse skin.

Keywords
zinc oxide
mitotic index
epidermal basal cells
mouse skin
Amo Type
Article
Published Date
1994-10
Publication Title
Acta Medica Okayama
Volume
volume48
Issue
issue5
Publisher
Okayama University Medical School
Start Page
231
End Page
236
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT