JaLCDOI 10.18926/AMO/32685
FullText URL fulltext.pdf
Author Katayama, Sho| Hori, Yasuo| Inokuchi, Seiji| Hirata, Toshihiko| Hayashi, Yasushi|
Abstract <p>Theta activity in EEG was found to be augmented in the frontal midline area in 5 young women while they played classical piano pieces and during related mental tasks. This activity was considered to be a frontal midline theta rhythm with the maximal amplitude mostly in Fz and of the frequency ranging from 5 to 7.5 Hz. This theta activity was observed to increase depending on the degree of the subjects' concentration on piano playing or related tasks. In bilateral parietal derivations, increases in the power value of alpha activity were observed in some subjects while they were listening to music, suggesting that alpha activity was involved in appreciation of music.</p>
Keywords frontal midline theta rhythm EEG music piano playing mental concentration
Amo Type Article
Published Date 1992-02
Publication Title Acta Medica Okayama
Volume volume46
Issue issue1
Publisher Okayama University Medical School
Start Page 23
End Page 29
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1561902
Web of Sience KeyUT A1992HH01700005
JaLCDOI 10.18926/AMO/32391
FullText URL fulltext.pdf
Author Hattori, Yukio| Moriwaki, Akiyoshi| Yasuhara, Hiromichi| Nishida, Nobuyoshi| Hori, Yasuo|
Abstract <p>A microinjection of ferric chloride solution into the left frontal cortex of rats induced epileptic discharges which were recorded by electrocorticography. In animals having such electrographic seizure activity 30 to 60 days after the injection, the accumulation of cyclic AMP elicited by norepinephrine was examined in slices from four cortical regions. The accumulation was significantly greater in the left anterior area, into which region the ferric chloride solution was injected, than in the right anterior area. There was also a tendency for greater norepinephrine-elicited accumulation of cyclic AMP to occur in the left posterior area than in the right posterior area.</p>
Keywords rat cerebral cortex iron-induced epileptic discharge cortical slices cyclic AMP norepinephrine
Amo Type Brief Note
Published Date 1983-08
Publication Title Acta Medica Okayama
Volume volume37
Issue issue4
Publisher Okayama University Medical School
Start Page 377
End Page 380
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6312769
Web of Sience KeyUT A1983RE57600010
JaLCDOI 10.18926/AMO/32390
FullText URL fulltext.pdf
Author Hattori, Yukio| Inaba, Kozo| Moriwaki, Akiyoshi| Nishida, Nobuyoshi| Yasuhara, Hiromichi| Hori, Yasuo|
Abstract <p>An epileptic focus not resulting in generalized convulsions was induced by a microinjection of ferric chloride solution into the left anterior cortex of rats. The formation of the epileptic focus was confirmed by the appearance of bilateral spike and slow wave complexes as well as focal isolated spikes in electrocorticograms (ECoGs). The effect of glutamate on cyclic AMP accumulation was examined in incubated slices prepared from four quadrants of the epileptic cortex. In animals showing isolated spikes 8 to 10 days after the microinjection, the effect of glutamate on cyclic AMP accumulation was stimulatory. It was greatest in the left anterior quadrant which included the injection site, but only slight in the left and right posterior quadrants. In animals showing spike and slow wave complexes 30 to 60 days after the microinjection, the stimulatory effect of glutamate was also most pronounced in the left anterior quadrant. In the right anterior and the left posterior quadrants glutamate had almost no effect, while in the right posterior quadrant, glutamate was inhibitory.</p>
Keywords rat cerebral cortex iron-induced epileptic focus cortical slices glutamate cyclic AMP
Amo Type Article
Published Date 1983-08
Publication Title Acta Medica Okayama
Volume volume37
Issue issue4
Publisher Okayama University Medical School
Start Page 291
End Page 299
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6137941
Web of Sience KeyUT A1983RE57600003
JaLCDOI 10.18926/AMO/31926
FullText URL fulltext.pdf
Author Hattori, Yukio| Moriwaki, Akiyoshi| Hayashi, Yasushi| Hori, Yasuo|
Abstract <p>Accumulation of cyclic AMP elicited by glutamate was examined in slices from different cortical areas of rats 30 to 60 days after ferrous chloride solution was injected into the left sensorimotor cortex to induce an epileptic focus. In the anterior cortex of rats showing dominant electrographic spike activity on either side of the cortex, the glutamate-elicited accumulation of cyclic AMP was greater on the dominant side than on the other. In the anterior cortex of rats showing nearly equal spike activity on either side, the accumulation was greater on the side ipsilateral to the injection site than on the other. Different inhibitory effects of 3-isobutyl-1-methylxanthine on the elicitation of cyclic AMP accumulation by glutamate was observed in relation to the patterns of spike activity.</p>
Keywords cyclic AMP glutamate 3-isobuty-1-methylxanthine rat cerebral cortex ironinduced epilepsy
Amo Type Article
Published Date 1986-10
Publication Title Acta Medica Okayama
Volume volume40
Issue issue5
Publisher Okayama University Medical School
Start Page 277
End Page 280
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2431600
Web of Sience KeyUT A1986E557800007
JaLCDOI 10.18926/AMO/31742
FullText URL fulltext.pdf
Author Moriwaki, Akiyoshi| Hattori, Yukio| Hayashi, Yasushi| Kusai, Yutaka| Hori, Yasuo|
Abstract <p>Cyclic AMP accumulation in response to norepinephrine was examined in slices of rat cerebral cortex the day after a unilateral application of anodal current of 0.3, 3.0 or 30 microA to the surface of the sensorimotor cortex. When 3.0 microA was applied, the norepinephrine-elicited accumulation of cyclic AMP was greater in the cortical area including the application point than in either the contralateral cortical area or non-polarized control cortical slices. The changes in cyclic AMP accumulation are discussed in relation to the role of the direct current in producing functional changes in the cortex.</p>
Keywords rat cerebral cortex norepinephrine cyclic AMP polarization
Amo Type Brief Note
Published Date 1987-12
Publication Title Acta Medica Okayama
Volume volume41
Issue issue6
Publisher Okayama University Medical School
Start Page 285
End Page 288
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2830766
Web of Sience KeyUT A1987L530300008
JaLCDOI 10.18926/AMO/31525
FullText URL fulltext.pdf
Author Moriwaki, Akiyoshi| Hattori, Yukio| Hayashi, Yasushi| Sunami, Takaaki| Hori, Yasuo|
Abstract <p>In iron-induced epilepsy, partial section of the corpus callosum resulted in a decrease in rats showing dominant spike activity on the side of secondary focus and an increase in rats showing almost equal spike activity on the sides of primary and secondary focus in electrocorticograms (ECoGs). Changes in ECoG spike frequencies caused by sectioning the corpus callosum included an increase in unilateral spikes on the side of primary focus, a decrease in unilateral spikes on the side of secondary focus, and an increase in bilateral spikes appearing almost synchronously on both sides.</p>
Keywords corpus callosum cerebral cortex iron-induced epilepsy electrocorticographic spike activity rat
Amo Type Brief Note
Published Date 1985-10
Publication Title Acta Medica Okayama
Volume volume39
Issue issue5
Publisher Okayama University Medical School
Start Page 421
End Page 424
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 4072771
Web of Sience KeyUT A1985ATK7300008
JaLCDOI 10.18926/AMO/31504
FullText URL fulltext.pdf
Author Hattori, Yukio| Moriwaki, Akiyoshi| Hayashi, Yasushi| Sunami, Takaaki| Hori, Yasuo|
Abstract <p>The appearance of epileptiform discharges in electrocorticograms was induced by a unilateral injection of CoCl2 solution into the sensorimotor cortex of rats. Accumulation of cyclic AMP elicited by ouabain or a high concentration of potassium ions was determined in slices from different cortical areas of rats 9 or 10 days after the injection. In the anterior cortex, the depolarization-elicited accumulation of cyclic AMP was significantly higher in the cortical area ipsilateral to the injection site than in the contralateral cortical area. In the posterior cortex, a similar but not significant difference in the accumulation of cyclic AMP was noted.</p>
Keywords cobalt-induced epilepsy rat cerebral cortex slices depolarization cyclic AMP
Amo Type Brief Note
Published Date 1985-12
Publication Title Acta Medica Okayama
Volume volume39
Issue issue6
Publisher Okayama University Medical School
Start Page 489
End Page 492
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3004112
Web of Sience KeyUT A1985AWT4000009
JaLCDOI 10.18926/AMO/31259
FullText URL fulltext.pdf
Author Hattori, Yukio| Uezu, Eiko| Moriwaki, Akiyoshi| Hori, Yasuo|
Abstract <p>In rats, microinjection of FeCl3 solution into the left sensorimotor cortex was performed to induce a chronic epileptic focus. One month or more after the microinjection, electrocutaneous stimuli were applied to part of the wrist joint and 50 consecutive somatosensory evoked potentials (SEPs) were averaged. SEP from the left cortex showed only an initial negative monophasic deflection while SEP from the contralateral cortex showed a normal configuration with initial positive-negative biphasic deflection in the majority of experimental animals.</p>
Keywords somatosensory EVP iron-induced focus rat.
Amo Type Brief Note
Published Date 1981-12
Publication Title Acta Medica Okayama
Volume volume35
Issue issue6
Publisher Okayama University Medical School
Start Page 431
End Page 433
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6459715
Web of Sience KeyUT A1981MV25300008
JaLCDOI 10.18926/AMO/31254
FullText URL fulltext.pdf
Author Hattori, Yukiko| Inaba, Kozo| Hori, Yasuo|
Abstract <p>The effect of L-glutamate of cyclic AMP levels in different areas of rat cerebral cortex was examined during the development of an iron-induced focus in the left sensorimotor cortex. The addition of L-glutamate resulted in increased cyclic AMP levels in slices from the quarter of cortex with the iron-induced focus. The levels lowered in slices from the quarter of cortex most remote from the focus. Thus L-glutamate showed stimulatory and inhibitory effects on the accumulation of cyclic AMP.</p>
Keywords rat cerebral cortex cyclic AMP <sub>L</sub>-glutamate iron-induced focus.
Amo Type Brief Note
Published Date 1981-10
Publication Title Acta Medica Okayama
Volume volume35
Issue issue4
Publisher Okayama University Medical School
Start Page 289
End Page 291
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6117191
Web of Sience KeyUT A1981MK84200008
JaLCDOI 10.18926/AMO/31123
FullText URL fulltext.pdf
Author Islam, Nadira| Moriwaki, Akiyoshi| Hattori, Yukio| Hori, Yasuo|
Abstract <p>An anodal direct current of 3.0 microA or 30.0 microA was unilaterally applied for 30 min or 3 h to the surface of the sensorimotor cortex of rats, and the effects of polarization on the morphology of brain cells were examined by light microscopy. After five repeated anodal polarization trials, dark neurons appeared mainly in the polarized neocortex regardless of the intensity and duration of the polarizing currents. Such dark neurons were scarce in the control animals or the animals receiving only one trial of polarization. The dark neurons were most abundant in the second to fourth layers of the ipsilateral superior-lateral convexity of the frontal cortex, but a few were present in the contralateral cortex. The dark neurons began to appear 24 h after the last polarization; thereafter almost all of these neurons gradually reverted to their normal morphological profiles through a transitory state within 1 month of the last trial of repeated polarization. No morphological changes were apparent in any of the brain structures other than the cerebral cortex. These findings indicate that repeated anodal polarization has reversible morphological effects on the cortical neurons, suggesting that the appearance of dark neurons after anodal polarization is an important index for evaluation of cortical plastic change induced by polarization.</p>
Keywords anodal polarization direct current dark neuron cerebral cortex rat
Amo Type Article
Published Date 1994-06
Publication Title Acta Medica Okayama
Volume volume48
Issue issue3
Publisher Okayama University Medical School
Start Page 123
End Page 130
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7942070
Web of Sience KeyUT A1994NV04300002
JaLCDOI 10.18926/AMO/31117
FullText URL fulltext.pdf
Author Jin, Li| Murakami, Tetuhide H| Janjua, Najma a| Hori, Yasuo|
Abstract <p>The purpose of this study was to investigate the effects of topical treatment with zinc oxide (2.5%, 10%, 25% and 50%) and intraperitoneal treatment with diethyldithiocarbamate (DEDTC) (50 mg/kg, 500 mg/kg and 1,000 mg/kg) on the mitotic index of epidermal basal cells in incised and non-incised mouse skin. The present results showed that topical application of zinc oxide (25% and 50%) increased the mitotic index of epidermal basal cells in incised skin and non-incised skin. Conversely, intraperitoneal administration of DEDTC (500 mg/kg and 1,000 mg/kg) decreased the mitotic index, but only in the incised skin. These results suggest that mitosis of epidermal basal cells may be stimulated by the topical application of zinc oxide both in incised and non-incised mouse skin, and that it also may be inhibited by the intraperitoneal administration of DEDTC in incised mouse skin.</p>
Keywords zinc oxide mitotic index epidermal basal cells mouse skin
Amo Type Article
Published Date 1994-10
Publication Title Acta Medica Okayama
Volume volume48
Issue issue5
Publisher Okayama University Medical School
Start Page 231
End Page 236
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7863793
Web of Sience KeyUT A1994PP23600001
JaLCDOI 10.18926/AMO/31106
FullText URL fulltext.pdf
Author Lu, Yun-Fei| Hattori, Yukio| Hayashi, Yasushi| Hori, Yasuo|
Abstract <p>Anodal direct currents at intensities ranging from 0.3 to 30.0 microA were unilaterally applied for 30 min once a day to the premotor area of the rabbit cerebral cortex. The anodal polarization was repeated 10 times at intervals of 2-3 days, and the effect on the motor activity of the forelimbs during and after each polarization trial was compared with that before polarization. Peripheral motor activity was classified as either gentle flexion of forelimbs or struggle with violent movement of forelimbs. A current of 0.3 microA caused no change in motor behavior. Flexion of the forelimb contralateral to the polarized cortex was clearly increased when a polarizing current of 1.0 or 3.0 microA was applied, and peak flexion was observed between the third and seventh polarization trials. A current of 10 or 30 microA had no effect on forelimb flexion. Conversely, forelimb struggle on both sides was decreased when 10.0 or 30.0 microA, but not 1.0 or 3.0 microA, was applied. These results show that anodal polarization of the cerebral cortex exerts dual effects on peripheral motor activity, probably through changes in cortical excitability associated with the current intensity.</p>
Keywords anodal polarization dominant focus motor behavior cerebral cortex rabbit
Amo Type Article
Published Date 1994-04
Publication Title Acta Medica Okayama
Volume volume48
Issue issue2
Publisher Okayama University Medical School
Start Page 81
End Page 86
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8042537
Web of Sience KeyUT A1994NJ77500003
JaLCDOI 10.18926/AMO/31097
FullText URL fulltext.pdf
Author Moriwaki, Akiyoshi| Hattori, Yukio| Hayashi, Yasushi| lu, Yun-fei| Islam, Nadira| Hori, Yasuo|
Abstract <p>A unilateral 30-min application of anodal direct current to the promotor cortex of rabbits was repeated 10 times, and cyclic AMP accumulation in response to histamine was investigated in slices of different cortical areas. Polarization with 1.0 microA decreased the cyclic AMP accumulation in the cortical area contralateral to the polarization, by which regional dominance in cyclic AMP accumulation was produced in the polarized cortex. In contrast, the regional difference in cyclic AMP accumulation was reversed when 10.0 or 30.0 microA was applied. The histamine-elicited accumulation of cyclic AMP was almost completely inhibited by the selective H2-receptor antagonist cimetidine. These results suggest that repeated anodal polarization regionally alters H2-receptor-mediated cyclic AMP generation in the cortex depending on the intensity of the polarizing currents and this pattern of cyclic AMP accumulation is responsible for the characteristic motor behavior induced by anodal polarization.</p>
Keywords anodal polarization cyclic AMP histamine cerebral cortex rabbit
Amo Type Article
Published Date 1994-12
Publication Title Acta Medica Okayama
Volume volume48
Issue issue6
Publisher Okayama University Medical School
Start Page 323
End Page 326
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7709760
Web of Sience KeyUT A1994PZ34600007
JaLCDOI 10.18926/AMO/31018
FullText URL fulltext.pdf
Author Hayashi, Yasushi| Hattori, Yukio| Moriwaki, Akiyoshi| Asaki, Hideki| Hori, Yasuo|
Abstract <p>The effects of prolonged weak anodal direct current (DC) on the electrocorticogram (ECoG) were investigated in awake rabbits. When the current (20-40 microA) was applied to the motor region of the cerebral cortex, seizure activity in the ECoG appeared from the frontal cortex. Repeated application of the DC decreased the threshold current for producing the seizure activity. Diazepam significantly elevated the threshold of the seizure activity. In contrast to the marked changes in the ECoG, no behavioral changes were observed during or after the application of weak anodal DC. The changes in the ECoG are discussed in relation to the intensity and duration of the DC.</p>
Keywords rabbit cerebral cortex anodal direct current electrocorticogram seizure activity diazepam
Amo Type Article
Published Date 1988-10
Publication Title Acta Medica Okayama
Volume volume42
Issue issue5
Publisher Okayama University Medical School
Start Page 293
End Page 296
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3223340
Web of Sience KeyUT A1988Q771900007
JaLCDOI 10.18926/AMO/30700
FullText URL fulltext.pdf
Author Uezu, Eiko| Hori, Yasuo|
Abstract <p>Under barbiturate anesthesia, male Wistar rats weighing 250-300 g were injected with 2.5 microliters of 0.2 M FeCl3 solution into the left sensori-motor cortex to induce an epileptic focus with minimal abnormal activities. Polygraphy started 1 week after the surgery, showed a spindle-like hypersynchronous activity that appeared not only in the slow wave sleep period but also during paradoxical sleep (PS). This activity had a frequency of 8-14 Hz. The amplitude was more than 200 mu v in the right (non-injected side) cortex but very small in the left cortex (injected side). Isolated spike discharges were observed in an ECoG of slow wave sleep. Apart from this activity there was nothing resembling the usual sleep spindles.</p>
Keywords iron-induced focus paradoxical sleep spindle-like activity
Amo Type Brief Note
Published Date 1982-06
Publication Title Acta Medica Okayama
Volume volume36
Issue issue3
Publisher Okayama University Medical School
Start Page 237
End Page 240
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7113750
Web of Sience KeyUT A1982NV62100010
JaLCDOI 10.18926/AMO/30657
FullText URL fulltext.pdf
Author Hattori, Yukio| Inaba, Kozo| Moriwaki, Akiyoshi| Hori, Yasuo|
Abstract <p>A chronic epileptic focus not resulting in generalized convulsions was induced by a microinjection of FeCl3 solution into the left anterior cortex of rats. Cyclic AMP accumulation in response to adenosine was examined in incubated slices from the cerebral cortex of animals that showed bilateral spike and slow wave complex in an electrocorticogram (ECoG) 30 to 60 days after the microinjection. Cyclic AMP accumulation after incubation with adenosine was most marked in slices from the left anterior quadrant of the cortex including a FeCl3-injected site. A medium response was observed in both the left posterior and the right anterior quadrants, but little or no response in the right posterior quadrant of the cortex.</p>
Keywords rat cerebral cortex iron-induced epileptic focus cyclic AMP adenosine
Amo Type Brief Note
Published Date 1982-08
Publication Title Acta Medica Okayama
Volume volume36
Issue issue4
Publisher Okayama University Medical School
Start Page 313
End Page 316
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6291336
Web of Sience KeyUT A1982PE61100009
JaLCDOI 10.18926/AMO/30345
FullText URL fulltext.pdf
Author Hattori, Yukio| Moriwaki, Akiyoshi| Yasuhara, Hiromichi| Nishida, Nobuyoshi| Hori, Yasuo|
Abstract <p>Ferrous chloride solution was injected unilaterally into the sensorimotor cortex of rats to induce a chronic epileptic focus. Accumulation of cyclic AMP elicited by depolarizing agents was determined in slices from different cortical areas of rats 30-60 days after the injection. In anterior cortical areas which include the sensorimotor cortex, the cyclic AMP accumulation elicited by ouabain or a high concentration of potassium ion was greater in electrographic spike activity on the dominant side than on the other. In posterior cortical areas, no difference in cyclic AMP accumulation was detected. The regional difference in the depolarization-elicited accumulation of cyclic AMP is discussed with regard to the process of epileptic focus.</p>
Keywords cyclic AMP depolarization cortical slices ferrous chloride focal epilepsy rat
Amo Type Brief Note
Published Date 1984-10
Publication Title Acta Medica Okayama
Volume volume38
Issue issue5
Publisher Okayama University Medical School
Start Page 487
End Page 491
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6097100
Web of Sience KeyUT A1984TQ61100010