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Okada, Yoshiki Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Abe, Nobuhiro Department of Orthopaedic Surgery and Sport Medicine, General Medical Center Kawasaki Medical School
Hisamori, Noriyuki Department of Science and Engineering, Sophia University
Kaneeda, Toshiaki Department of Mechanical System Engineering, Okayama University of Science
Moriyama, Shigeaki Department of Mechanical Engineering, Fukuoka University
Ohmori, Hitoshi Riken Ohmori Materials Fabrication Laboratory
Mizutani, Masayoshi Department of Mechanical Systems and Design, Graduate School of Engineering, Tohoku University
Yanai, Hiroyuki Department of Pathology, Okayama University Hospital
Nakashima, Yoshio Nakashima Medical Co., Ltd.
Yokoyama, Yusuke Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ozaki, Toshifumi Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kakenhi
Abstract
Metals have been used clinically as biomaterials, especially in the orthopaedic and dental fields. Metals used as implants wear at contact surfaces, producing metal particles and metal ions that may be harmful. Newly developed metal implants and methods of implant surface modification are currently under scrutiny. We evaluated the use of electrolytic in-process dressing (ELID) as a surface finishing method for metal implants. Metal implants processed using the ELID method (ELID group) or not processed (Non-ELID group) were inserted surgically into rabbit femurs. The rabbits were sacrificed postoperatively over a 24-week period. We assessed the concentrations of the cytokines, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, the resistance to implant pull-out, and histopathology at the implant site. There was no significant difference between the groups regarding the cytokine concentrations or implant pull-out resistance. Many particles indicating wear around the implant were noted in the Non-ELID group (n=10) but not the ELID group (n=13), while a fibrous membrane adhering to the every implant was noted in the ELID group. The formation of a fibrous membrane rather than metal particles in the ELID group may indicate improved biocompatibility, and it suggests that ELID may prevent corrosion in the areas of contact.
Keywords
biomaterial
surface modification
metal implant
wear
metal ion
Published Date
2017-02
Publication Title
Acta Medica Okayama
Volume
volume71
Issue
issue1
Publisher
Okayama University Medical School
Start Page
49
End Page
57
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2017 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Amo Type
Original Article
Submission Path
amo/vol71/iss1/7
JaLCDOI