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Recent evidence suggests that the AKT1-GSK3Β signalling cascade partially mediates dopaminedependentbehaviours. In relation to the pathophysiology of schizophrenia or methamphetamine (Meth)use disorder, AKT1 is a good candidate gene for such conditions. For schizophrenia, positive associationsof SNPs and AKT1 haplotypes were reported in US and Japanese samples. To evaluate the association between AKT1 and Meth-use disorder, we conducted a case-control study of Japanese samples (182 patients and 437 controls). A positive association between a SNP and haplotypes was found, and the ‘signal’ SNP was the same SNP found to be associated with US schizophrenia, but not with Japanese schizophrenia. Our results indicate that AKT1 may play a possible role in the development of Meth-use disorder. Further investigation of these associations, together with evidence from previous animal studies, may open the way to elucidation of the pathophysiology of this condition.
Digital Object Identifier:10.1017/S1461145705005481
Published with permission from the copyright holder. This is the institute's copy, as published in The International Journal of Neuropsychopharmacology, Feb. 2006, Volume 9, Issue 1, Pages 77-81.
Copyright © 2005 Collegium Internationale Neuropsychopharmacologicum. All rights reserved.
The International Journal of Neuropsychopharmacology