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ID 32998
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Author
Koizumi, Hiroki
Hashimoto, Kenji
Kumakiri, Chikara
Shimizu, Eiji
Sekine, Yoshimoto
Ozaki, Norio
Inada, Toshiya
Harano, Mutsuo
Komiyama, Tokutaro
Yamada, Mitsuhiko
Sora, Ichiro
Ujike, Hiroshi
Takei, Nori
Iyo, Masaomi
Abstract
Several lines of evidence suggest that increased generation of auto-oxidized dopamine (DA) o-quinone is associated with the neurotoxicity of methamphetamine (MAP) in the brain, and that, as a cellular defenses against DA-derived quinines, glutathione S-transferase (GST) detoxifies auto-oxidized DA o-quinone in the brain. Glutathione S-transferase M1 (GSTM1) of the mu-class of GSTs catalyzes reaction between glutathione and catecholamine o-quinones under physiological conditions. This study was undertaken to investigate the role of the GSTM1 gene deletion polymorphism in the neuropathology of MAP abuse. One hundred fifty-seven MAP abusers and 200 healthy comparison subjects were tested for a genetic polymorphism of GSTM1. The difference in the frequency of deletion (D)/nondeletion (N) alleles between the female abusers and female controls was close to statistical significance (P=0.071), although there was no statistical difference (P=0.651) between male abusers and male controls. Furthermore, the number of female abusers with deletion alleles was significantly (P=0.007, odds ratio: 2.77, 95% CI 1.30-5.89) higher than that of male abusers with deletion alleles. These findings suggest that GSTM1 gene deletion may contribute to a vulnerability to MAP abuse in female subjects, but not in male subjects. (C) 2003 Wiley-Liss, Inc.
Keywords
methamphetamine
drug abuse
Glutathione S-transferase
gender difference
Note
Digital Object Identifer:10.1002/ajmg.b.20148
Published with permission from the copyright holder. This is the author's copy, as published in American Journal of Medical Genetics Part B, Neuropsychiatric Genetics, Apr 2004, Volume 126B, Issue 1, Pages 43-45.
Publisher URL:http://dx.doi.org/10.1002/ajmg.b.20148
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Copyright © 2003 Wiley-Liss, Inc. All rights reserved.
Published Date
2004-04-01
Publication Title
American Journal of Medical Genetics Part B, Neuropsychiatric Genetics
Volume
volume126B
Issue
issue1
Publisher
Wiley-Liss, Inc.
Start Page
43
End Page
45
ISSN
0148-7299
NCID
AA11815089
Content Type
Journal Article
language
英語
Copyright Holders
Wiley-Liss, Inc.
File Version
author
Refereed
True
DOI
PubMed ID
Web of Sience KeyUT
Submission Path
biology_general/31