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ID 32984
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Author
Hashimoto, Tasuku
Hashimoto, Kenji
Matsuzaka, Daisuke
Shimizu, Eiji
Sekine, Yoshimoto
Yoshiya, Inada
Iwata, Nakao
Harano, Mutsuo
Komiyama, Tokutaro
Yamada, Mitsuhiko
Sora, Ichiro
Ujike, Hiroshi
Iyo, Masaomi
Abstract
Several lines of evidence suggest that oxidative stress plays a role in the mechanisms of action of methamphetamine (MAP) in the human brain. Given the role of glutathione S-transferases (GSTs) in the protection against oxidative stress, genes encoding the GSTs have been considered as candidates for association studies of MAP abuse. This study was undertaken to investigate the role of the functional polymorphism of GSTP1 gene exon 5 (Ile105Val) in the pathogenesis of MAP abuse. Genotyping for GSTP1 gene polymorphism exon 5 (Ile105Val) in 189 MAP abusers and 199 normal controls was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Association between GSTP1 gene polymorphism and clinical features (prognosis of psychosis (transient-type and prolonged-type), spontaneous relapse (positive and negative), and poly-substance abuse) of MAP abusers was evaluated. Significant differences in the frequency of both alleles (P = 0.026, odds ratio: 1.70, 95% confidence intervals (CI) 1.06-2.72) and genotypes (P = 0.029) between MAP abusers and controls were detected. In particular, a significant difference in both genotype frequency (P = 0.013) and allele frequency (P = 0.014, odds ratio: 1.84, 95% CI 1.13-2.97) between MAP abusers with psychosis (transient-type and prolonged-type) and controls was detected. Our findings suggest that the polymorphism (Ile 105Val) on exon 5 of the GSTP1 gene may contribute to a vulnerability to psychosis associated with MAP abuse in Japanese population.
Keywords
methamphetamine
psychosis
drug abuse
genetic factor; polymorphism
Note
Digital Object Identifer: 10.1002/ajmg.b.30164
Published with permission from the copyright holder. This is the author's copy, as published in American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, May 2005, Volume 135B, Issue 1, Pages 5-9.
Publisher URL:http://dx.doi.org/10.1002/ajmg.b.30164
Direct access to Thomson Web of Science record
Copyright © 2005 Wiley-Liss, Inc. All rights reserved.
Published Date
2005-05-05
Publication Title
American Journal of Medical Genetics Part B, Neuropsychiatric Genetics
Volume
volume135B
Issue
issue1
Publisher
Wiley-Liss, Inc.
Start Page
5
End Page
9
ISSN
1552-4841
NCID
AA11815089
Content Type
Journal Article
language
英語
Copyright Holders
Wiley-Liss, Inc.
File Version
author
Refereed
True
DOI
PubMed ID
Web of Sience KeyUT
Submission Path
biology_general/26