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ID 32982
FullText URL
Author
Hayashi, Mitsuko
Yatsushiro, Shouki
Ishio, Shougo
Yamamoto, Akitsugu
Abstract
Microvesicles in endocrine cells are the morphological and functional equivalent of neuronal synaptic vesicles. Microvesicles accumulate various neurotransmitters through a transmitter-specific vesicular transporter energized by vacuolar H+-ATPase. We found that mammalian pinealocytes, endocrine cells that synthesize and secrete melatonin, accumulate L-glutamate in their microvesicles and secrete it through exocytosis. Pinealocytes use L-glutamate as either a paracrine- or autocrine-like chemical transmitter in a receptor-mediated manner, resulting in inhibition of melatonin synthesis. In this article, we briefly describe the overall features of the microvesicle-mediated signal-transduction mechanism in the pineal gland and discuss the important role of acidic organelles in a novel regulatory mechanism for hormonal synthesis and secretion.
Keywords
V-ATPase
melatonin
L-glutamate
serotonin
paracrine
autocrine
pinealocyte
endocrine cell.
Note
Published with permission from the copyright holder. This is the institute's copy, as published in The Journal of Experimental Biology, January 2000, Volume 203, Issue 1, Pages 117-125.
Publisher URL:http://jeb.biologists.org/cgi/reprint/203/1/117
Copyright © 2000 The Company of Biologists Limited. All rights reserved.
Published Date
2001-01
Publication Title
The Journal of Experimental Biology
Volume
volume203
Issue
issue1
Publisher
The Company of Biologists Limited
Start Page
117
End Page
125
ISSN
0022-0949
NCID
AA00697490
Content Type
Journal Article
language
英語
Copyright Holders
The Company of Biologists Limited
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT
Submission Path
biology_general/9