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ID 15907
Eprint ID
15907
FullText URL
Thumnail 100_351.pdf 6.15 MB
Title Alternative
Tissue cathepsin B activity and serum inhibitory factor of cathepsin B activity in patients with liver cancer
Author
Hashimoto, Makoto
Abstract
Liver tissue cathepsin B (EC 3.4.22.1) activity was measured with N-benzyloxy-carbonyl-L-arginyl-L-arginine-4-methyl-7-coumarilamide (Z-Arg-Arg-MCA) as the substrate in order to clarify the role of this enzyme in tumor invasion or metastasis of liver cancer. Serum inhibitory factor of cathepsin B activity was also determined in cirrhotic patients with hepatocellular carcinoma and in patients with other liver diseases.Cathepsin B activity of liver cancer tissues in patients with lung metastasis was higher than that in non-cancerous tissue sourrounding the main tumor. The levels of serum inhibitory factor of cathepsin B activity in patients with hepatocellular carcinoma were lower than those in healthy subjects or non-malignant chronic liver diseases. Furthemore, in hepatocellular carcinoma patients with portal invasion, serum levels of inhibitory factor of cathepsin B activity were much lower than those with no portal invasion.The results suggest that cathepsin B activity participates in tumor invasion and metastasis of liver cancer due to imbalance of enzyme-inhibitor relationship.
Keywords
肝癌
カテプシンB
血清中カテプシンB阻害因子
浸潤
転移
Published Date
1988
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume100
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
351
End Page
360
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/100/3-4/100_3-4_351/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma