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ID 13785
Eprint ID
13785
FullText URL
Thumnail 106_811.pdf 2.79 MB
Title Alternative
Induction of renal metallothionein in ischemic acute renal failure in the rat
Author
Harada, Keiko
Abstract
To clarify the functions of the renal metallothioneins (MTs) in rats following ischemic acute renal failure, the expression of MT mRNA and the localization of MT in rats undergoing 60 min of bilateral renal artery clamp ischemia followed by reperfusion was examined by Northern blot analysis, in situ hybridization and immunohistochemical analysis. Induction of maximum at 1 to 3 days followed by a gradual decrease. Histlogically, both MT mRNA and MT were detected in renal tubular cells intensely and specifically in the outer medulla at 1 day after release of the clamp. These findings suggest that MTs protect the tubular cells by scavenging the free radicals, which probably cause renal tubular cell damage by ischemia-reperfusion, and that MTs provide the zinc ions to zinc-requiring apo-enzymes necessary for healing and regenerating renal tubular cells.
Keywords
虚血性急性腎不全
メタロチオネイン
in situ hybridization
免疫組織化学染色
Note
原著
Published Date
1994-08
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume106
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
811
End Page
823
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/106/7-8/106_7-8_811/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma