JaLCDOI 10.18926/AMO/31899
FullText URL fulltext.pdf
Author Yamamoto, Michio| Kojima, Sumikazu| Tanimoto, Jun-ichi| Nobuki, Shigeo| Hagitani, Akira| Nishishita, Soichi| Shiwaki, Midori| Utsumi, Kozo|
Abstract <p>1. The unsaturated fatty acid fraction (OX) from the liver of irradiated rabbits contains substance which has the same effects as X-ray irradiation on the testicular cells. 2. This substance introduced intravenously causes the degeneration of the germinal cells with the formation of giant cells or multi-nucleated cells and the mitotic abnormalities. 3. The DNA content of the cell also shows the changes exactly identical with that seen after X-ray irradiation. 4. From these results we conclude that the X-ray injury will be mainly due to the production of some toxic substance which is found in the unsaturated fatty acid fraction and severely affects the cells in mitosis and DNA metabolism.</p>
Amo Type Article
Published Date 1960-04
Publication Title Acta Medicinae Okayama
Volume volume14
Issue issue1
Publisher Okayama University Medical School
Start Page 68
End Page 76
NCID AA00041342
Content Type Journal Article
language 英語
File Version publisher
Refereed True
NAID 120002313218
JaLCDOI 10.18926/AMO/31898
FullText URL fulltext.pdf
Author Yamamoto, Michio| Tanimoto, Junichi| Kojima, Sumikazu| Nobuki, Shigeo| Hagitani, Akira| Iguchi, Yoshiko| Akagi, Eiko| Ofuji, Tadashi| Asaka, Takakazu| Kamura, Junta| Shibata, Tsuneo|
Abstract <p>The unsaturated fatty acid fraction extracted from the liver of rabbit irradiated with X-rays exerts a strong cytotoxic effect on human coelothelioma cells and Yoshida sarcoma cells both in vitro and in vivo. The cell damage seems to initiate at the nucleus, finally leading to the complete cytolysis. The inhibiting effect of this substance on the mitosis of Yoshida sarcoma cells can be observed, especially marked from prophase up to metaphase giving almost the same results obtained after X-ray irradiation. From these results and the observations reported by several authors on the cell damage by X-ray irradiation, weshould call special attention to the fact that the essential mechanism of X-ray irradiation can be attributed to the cell toxin produced after the irradiation.</p>
Amo Type Article
Published Date 1960-04
Publication Title Acta Medicinae Okayama
Volume volume14
Issue issue1
Publisher Okayama University Medical School
Start Page 55
End Page 67
NCID AA00041342
Content Type Journal Article
language 英語
File Version publisher
Refereed True
NAID 120002313084