JaLCDOI 10.18926/AMO/32205
FullText URL fulltext.pdf
Author Shinozawa, Shinya| Gomita, Yutakata| Araki, Yasunori|
Abstract <p>&#60;P&#62;The tissue concentration of doxorubicin (adriamycin; ADM) and its major metabolite (aglycone I) was examined in mice pretreated with alpha-tocopherol (VE) or coenzyme Q10 (CoQ). In VE-pretreated group, the concentrations of aglycone I of the liver (1, 3 and 5 h after the administration), kidney (1 and 3h) and heart (3h) were significantly higher than those in the saline group. The clinical application of VE or CoQ concomitant with anti-tumor drugs especially ADM, requires caution.</p>
Keywords doxorubicin tissue concentration ?-tocopherol coenzymeQ10
Amo Type Article
Published Date 1991-06
Publication Title Acta Medica Okayama
Volume volume45
Issue issue3
Publisher Okayama University Medical School
Start Page 195
End Page 199
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1891979
Web of Sience KeyUT A1991FV15000011