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ID 31561
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Author
Hamazaki, Heisuke
Kato, Tomohiro
Yunoki, Yasuhiro
Mori, Masanobu
Gochi, Akira
Mimura, Hisashi
Orita, Kunzo
Abstract

To determine whether a relationship exists between DNA ploidy and the prognosis of hepatocellular carcinoma (HCC), flow cytometric DNA analysis was performed in paraffin-embedded specimens obtained from 44 patients with HCC who underwent hepatectomy. There were 26 diploid (59%) and 18 aneuploid (41%) tumors. No correlation was shown between DNA ploidy pattern and patient age, sex, liver cirrhosis, hepatitis B virus antigen and serum alpha-fetoprotein level. The ploidy pattern had no significant correlation with the presence of vascular invasion or intrahepatic metastasis. Only Edmondson's grade was well correlated with the ploidy pattern. We noted a significant correlation between survival rates and the presence of vascular invasion or intrahepatic metastasis (p < 0.05). In contrast, no significant correlation was found between DNA ploidy pattern and the prognosis of HCC. The results of this study indicate that DNA ploidy pattern may not be a useful indicator for the prognosis of HCCs after hepatic resection, unlike the results of gastric and colon cancers.

Keywords
DNA ploidy pattern
hepatocellular carcinoma
hepatic resection
prognosis
Amo Type
Article
Published Date
1993-12
Publication Title
Acta Medica Okayama
Volume
volume47
Issue
issue6
Publisher
Okayama University Medical School
Start Page
413
End Page
416
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT