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ID 31939
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Author
Sakagami, Kenichi
Takeuchi, Hitoshi
Tsuboi, Katsutoshi
Matsumoto, Takamasa
Tanaka, Kohtaro
Ohsaki, Toshihide
Horimi, Tadashi
Fuchimoto, Sadanori
Orita, Kunzo
Abstract

The survival rate of 19 patients who underwent living-related kidney transplantation after donor-specific blood transfusions (DST) was compared with that of 32 historical controls receiving transplants without DST. The graft survival rate of the DST group was 82% after two and three years. The graft survival rate of the DST group was significantly better than the 53% rate after two years obtained with the 32 historical controls (p less than 0.05). We tested sera from 16 DST-treated recipients to study the beneficial effect of DST on kidney allograft survival using the mixed lymphocyte culture (MLC) serum inhibition test. The results demonstrated that MLC inhibitory factors were induced in the serum of the recipient after completion of DST. This inhibition of MLC was observed by treatment of responder lymphocytes with serum obtained three weeks after DST plus rabbit complement. The inhibitory effect was also specific for responder cells in anti-donor MLC. Regarding the correlation with rejection episodes, these MLC inhibitory factors were often observed in the non-rejection group (p less than 0.05). The data suggest that such factors may be anti-idiotypic antibodies and be associated with prolonged graft survival.

Keywords
kidney transplantation
donor-specific blood transfusion (DST)
MLC inhibitory factors
anti-idiotypic antibody.
Amo Type
Article
Published Date
1986-02
Publication Title
Acta Medica Okayama
Volume
volume40
Issue
issue1
Publisher
Okayama University Medical School
Start Page
39
End Page
43
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT