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ID 42792
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Title Alternative
Effect of the Bone-Marrow Autolysate on Medullary Hematopoiesis Part II: Influence of bone-marrow autolysate under splenectomy, liver parenchymal disturbance or reticuloendotherial blockade
Author
Fujii, Masatomi
Abstract
In the previous report, the author stated that there should happen a remarkably stimulated medullary hematopoiesis if the intra-abdominal injection of bone-marrow extract were successively rendered for a normal rabbit; this time, I conducted the following experiments in order to clarify whether these phenomena would activate indirectly through liver, spleen, or reticuloendotherial syetem, which are said to keep close relation with hematopoiesis, or, as Miyakawa maintained in this so-called "autohormone tbeory", functionate directly. First, having successively injected "bone-marrow extract" at 48 hours as well as 7 days after the splenectomy, the author examined its peripheral blood picture: this time, as was seen in the case of normal rabbit, biphasic blood cell increase was observed to take place, and an increase of reticulocytes number as well as a left shift of leucocytes were observed conspicuously, under the secondary blood cell increase. Consequently, it was verified that the same extract could stimulated the medullary hematopoiesis even under the influence of splenectomy. Next, by injecting likewise at 24 hours after the liver parenchymal disturbance, biphasic blood cell increase, an increase of reticulocytes number, and a left shift of leucocytes were noticed; moreover, even in case when the functions both of liver and spleen were removed at the same time, almost the same result as in the normal rabbit was obtained. In case the reticuloendotherial system was blocked with India-ink, even successive injection could not cause either increase of blood cell as well as left shift of leucocyte or improvement of intramedullary blood stream; that is to say, no medullary hematopoiesis was brought about. From the above results, the author concludes that the improvement of medullary hematopoiesis by successive intraabdominal injection of bone-marrow extract has no concern with either splenectomy or liver parenchymal disturbance, that the soundness of bone-marrow reticuloendotherial system should be indispensable requisite, and that this phenomenon might occur owing to the direct stimulation to bone-marrow parenchymal function.
Published Date
1955-01-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume67
Issue
issue1
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
13
End Page
27
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/67/1/67_1_13/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma