JaLCDOI 10.18926/AMO/30493
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Author Teramoto, Norihito| Cao, liu| Kawasaki, Nobuhiro| Tonoyama, Yuji| Sarker, Ashit Baran| Yoshino, Tadashi| Takahashi, Kiyoshi| Akagi, Tadaatsu|
Abstract <p>&#60;P&#62;Reed-Sternberg cells (RS cells) of Hodgkin's disease (HD) are frequently infected with Epstein-Barr virus (EBV) and express EBV-encoded nonpolyadenylated RNA transcripts (EBER)-1. EBV latency has been classified into three distinct forms: Latency I, expressing only one of the latent proteins, EBV nuclear antigen (EBNA)-1, latency II, coexpressing EBNA-1 and LMPs, and latency III, expressing all latent viral proteins. RS cells express LMP-1 in addition to EBNA-1 and are considered to be EBV latency II frequently encountered in nasopharyngeal carcinoma. We examined 13 cases of EBV-infected HD by combined EBER-1 in situ hybridization and immunostaining for LMP-1. All of the RS cells expressed EBER-1, but a substantial number of EBER-1+ RS, cells were negative for LMP-1. The percentage of LMP-1+ RS cells out of EBER-1+ RS cells varied from 7% to 100% (average 69%). In this study, we showed that all EBV-infected RS cells were not restricted to latency II, and some belonged to latency I.&#60;/P&#62;</p>
Keywords in situ hybridization EBER-1 immunohistochemistry latecy
Amo Type Article
Published Date 1996-10
Publication Title Acta Medica Okayama
Volume volume50
Issue issue5
Publisher Okayama University Medical School
Start Page 267
End Page 270
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8914680
Web of Sience KeyUT A1996VQ20600006