JaLCDOI 10.18926/AMO/56250
FullText URL 72_5_515.pdf
Author Kanamitsu, Kiichiro| Chayama, Kousuke| Washio, Kana| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Shimada, Akira|
Abstract Hepatitis-associated aplastic anemia (HAAA) is an acquired bone marrow failure syndrome that develops after seronegative fulminant hepatitis. Abnormal cytotoxic T-cell activation with cytokine release is a possible pathophysiology. We present the case of a 16-month-old Japanese male who developed HAAA following living-donor liver transplantation for fulminant hepatitis. His aplastic anemia was successfully treated with immunosuppressive therapy. He had been administered tacrolimus for prophylaxis against hepatic allograft rejection. Ten years after the HAAA onset, the patient’s bone marrow was found to be slightly hypoplastic. Tacrolimus may be effective in controlling abnormal immune reactions that can cause recurrent impaired hematopoiesis.
Keywords hepatitis-associated aplastic anemia impaired hematopoiesis liver transplantation immunosuppressive therapy abnormal immune reaction
Amo Type Case Report
Published Date 2018-10
Publication Title Acta Medica Okayama
Volume volume72
Issue issue5
Publisher Okayama University Medical School
Start Page 515
End Page 518
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2018 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 30369609