JaLCDOI 10.18926/AMO/30797
FullText URL fulltext.pdf
Author Seymen, Oktay| Seven, Arzu| Candan, Gulden| Yigit, Gunnur| Hatemi, Sezer| Hatemi, Husrev|
Abstract <p>Our aim was to study the effect of iron supplementation on the following aspects of erythrocyte metabolism in experimental hyperthyroidism: glutathione (GSH) levels, glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities. Hyperthyroidism induced by L-thyroxine administrations significantly raised erythrocyte GSH, GSH-Px and SOD levels of the rats (P &#60; 0.001). Likewise, we observed that iron supplementation induced significant rises in erythrocyte GSH, GSH-Px and SOD levels (P &#60; 0.001) as compared with the control group. The erythrocyte GSH, GSH-Px and SOD levels of hyperthyroidism-induced iron-supplemented animals were significantly higher when compared with either the iron-supplemented group (P &#60; 0.001) or the only L-thyroxine-administered hyperthyroid group (P &#60; 0.001, P &#60; 0.05, P &#60; 0.01, respectively). The results of this study show that L-thyroxine administration and/or iron supplementation increases GSH, GSH-Px and SOD levels of erythrocytes.</p>
Keywords iron hyperthyroidism glutathione superoxide dismutase glutathione peroxidase
Amo Type Article
Published Date 1997-06
Publication Title Acta Medica Okayama
Volume volume51
Issue issue3
Publisher Okayama University Medical School
Start Page 129
End Page 133
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 9227791
Web of Science KeyUT A1997XJ12700003