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ID 10576
Eprint ID
10576
FullText URL
Thumnail 93_45_49.pdf 1.75 MB
Title Alternative
Induction of Atherosclerosis in Aorta and Coronary Artery of Chicken by Orally Administered Cholesterol
Author
Honjo, Sachika
Ohtsuki, Kazumasa
Abstract
Hypercholesterolemia and hyperlipidemia have been important in human health as factors that induce atherosclerotic lesions in brain and heart blood vessel. Various experimental studies have been done to prevent and treat atherosclerotic lesions in animals. In the present study, we assessed the suitability of chickens as experimental animal for atherosclerosis. Newly hatched chicks were fed on 1.0%-or 0.1%-cholesterol(CHO) containing feed. After 3 and 6 months, total cholesterol levels in the sera and histological changes in the aorta and coronary artery of chicks fed on 1.0%-CHO-containing feed for 3 and 6 months, intimal thickening and marked accumulation of foam cells were observed. Endothelial cells had disappeared in the aorta of these chicks. A slight accumulation of foam cells was observed in the aortic intima of chicks fed on 0.1%-CHO-containing feed. In the coronary artery, a remarkable thickening of intima with accumulation of foam cells and a marked stenosis of coronary space were observed in chicks fed on 1.0%-CHO-containing feed. The results of present study indicate that the chicken can be a useful experimental animal in the study of hypercholesterolemia, hyperlipidemia and atherosclerosis.
Keywords
experimental atherosclerosis
cholrsterol
chicks
Published Date
2004-02
Publication Title
岡山大学農学部学術報告
Publication Title Alternative
Scientific reports of the Faculty of Agriculture, Okayama University
Volume
volume93
Issue
issue1
Publisher
岡山大学農学部
Publisher Alternative
Faculty of Agriculture,Okayama University
Start Page
45
End Page
49
ISSN
0474-0254
NCID
AN00033029
Content Type
Departmental Bulletin Paper
language
日本語
File Version
publisher
Refereed
False
Eprints Journal Name
srfa