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ID 17289
Eprint ID
17289
FullText URL
Thumnail 90_527.pdf 524 KB
Title Alternative
Studies on anticomplementary activity in systemic lupus erythematosus: Part 2. Experimental studies
Author
Amano, Tetsuki
Abstract
The anticomplementary activity (ACA) of immune complexes or DNA was measured, then those data were compared with that in SLE sera. 1. High ACA was detected mainly in γ-GI and β-Gl fractions of SLE sera. 2. DNA (especially denatured DNA) showed high ACA, and the treatment with DNase eliminated its ACA. DNA did not bind nonspesifically to normal γ-Gl. 3. ACA in some SLE sera was reduced after DNase treatment. This treatment worked mainly on ACA of γ-Gl fraction. 4. The procedure of complement inactivation which is employed in measurement of ACA, depressed ACA of cryoglobulin, experimental immune complexes and SLE γ-GI fraction. This indicated that heat aggregation of native IgG could not account for high ACA in SLE sera. 5. The addition of enough amount of complement reduced ACA of immune complexes, but a certain level of ACA was still retained. 6. ACA of insoluble immune complex was much higher than that of soluble immune complex. These data may suggest that ACA in SLE sera originates from the circulating immune complexes, especially DNA-antiDNA antibody immune complexes and this ACA detected is the reflection of only a part of ACA caused by immune reaction in vivo.
Published Date
1978-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume90
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
527
End Page
536
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/90/5-6/90_5-6_527/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma