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ID 31767
JaLCDOI
FullText URL
Author
Takahashi, Tooru
Iijima, Yoshio
Matsumi, Masaki
Abe, Shinya
Itano, Yoshitaro
Kosaka, Futami
Abstract

The involvement of macrophages in the induction of metallothionein (MT) synthesis by bacterial endotoxin was studied in vitro. Rat peritoneal macrophages were incubated with endotoxin. The incubation medium from endotoxin-activated macrophages accelerated MT synthesis by human hepatic Chang cells. However, the incubation medium from non-activated macrophages did not. Endotoxin added to the culture medium of Chang cells was ineffective in inducing MT synthesis. The contents of zinc, copper and cadmium, which are primary inducers of MT, in the incubation medium of macrophages in the presence of endotoxin were not different from those in the absence of endotoxin. These results suggest that MT synthesis is induced by endotoxin-treated macrophages.

Keywords
metallothionein
endotoxin
macrophages
Change liver cells
Amo Type
Article
Published Date
1987-02
Publication Title
Acta Medica Okayama
Volume
volume41
Issue
issue1
Publisher
Okayama University Medical School
Start Page
19
End Page
23
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT