JaLCDOI 10.18926/AMO/31767
FullText URL fulltext.pdf
Author Takahashi, Tooru| Iijima, Yoshio| Matsumi, Masaki| Abe, Shinya| Itano, Yoshitaro| Kosaka, Futami|
Abstract <p>The involvement of macrophages in the induction of metallothionein (MT) synthesis by bacterial endotoxin was studied in vitro. Rat peritoneal macrophages were incubated with endotoxin. The incubation medium from endotoxin-activated macrophages accelerated MT synthesis by human hepatic Chang cells. However, the incubation medium from non-activated macrophages did not. Endotoxin added to the culture medium of Chang cells was ineffective in inducing MT synthesis. The contents of zinc, copper and cadmium, which are primary inducers of MT, in the incubation medium of macrophages in the presence of endotoxin were not different from those in the absence of endotoxin. These results suggest that MT synthesis is induced by endotoxin-treated macrophages.</p>
Keywords metallothionein endotoxin macrophages Change liver cells
Amo Type Article
Published Date 1987-02
Publication Title Acta Medica Okayama
Volume volume41
Issue issue1
Publisher Okayama University Medical School
Start Page 19
End Page 23
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3494383
Web of Science KeyUT A1987G146400003