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ID 13718
Eprint ID
13718
FullText URL
Thumnail 108_129.pdf 462 KB
Title Alternative
Suppression of liver metastasis by biological response modifiers (BRMs) and the significance of local immunity in the liver
Author
Takahashi, Masahiko
Abstract
Efficacy of a combination therapy with two biological response modifiers (BRMs), oral PSK and systemic IL-2, was evaluated in a mouse model system of hepatic metastasis from colon cancer. Hepatic metastasis was significantly suppressed and the duration of survival was significantly prolonged by combination therapy, but not by either therapy alone. The therapeutic effects were attributable to the mechanism that non-MHC restricted cytotoxicity of hepatic non-parenchymal lymphocytes activated by IL-2 was augmented by PSK-activated Kupffer cells with direct cell-to-cell contact. These results suggest that local immunity in the liver plays an important role in the formation and development of hepatic metastasis and that the combination of these two BRMs may provide an effective new clinical therapy.
Keywords
肝移転
肝リンパ球
クッパー細胞
PSK
interleukin 2 (IL-2)
Note
原著
Published Date
1996-06-29
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume108
Issue
issue3-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
129
End Page
137
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/108/3-6/108_3-6_129/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma