start-ver=1.4 cd-journal=joma no-vol=99 cd-vols= no-issue=11-12 article-no= start-page=1491 end-page=1502 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19871230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Seven Cases of Human Fascioliasis in and around Okayama Prefecture kn-title=岡山県および周辺県における肝蛭の人体寄生7症例について en-subtitle= kn-subtitle= en-abstract= kn-abstract=We have examined seven cases of fascioliasis in and around Okayama prefecture. Five cases were from Okayama prefecture, one case was from Hiroshima prefecture and the other one was from Hyogo prefecture. There were many cattle pastured for milk or beef in the place from where the patients came. The main symptoms were epigastralgia, right hypochondralgia and fever. We suspected fascioliasis by eosinophilia and space occupied lesions in the liver which were demonstrated by abdominal computed tomography or ultrasonography. Three cases were confirmed of the diagnosis by detection of the eggs in the feces or in the duodenal contents. Three other cases were diagnosed by skin test and sero-immunological techniques such as the Ouchterlony method and immunoelectrophoresis. One case was ectopic fascioliasis; the parasite wandered subcutaneously in the abdomen and was excised from the skin of the left hypochondrium. Treatment was carried out with bithionol administered orally at a dose of 50mg/kg on alternate days for 10 to 15 doses. In some cases, praziquantel was used at a dose of 75mg/kg for three days combined with bithionol. en-copyright= kn-copyright= en-aut-name=MatsuokaHiroyuki en-aut-sei=Matsuoka en-aut-mei=Hiroyuki kn-aut-name=松岡裕之 kn-aut-sei=松岡 kn-aut-mei=裕之 aut-affil-num=1 ORCID= en-aut-name=TonguYasumasa en-aut-sei=Tongu en-aut-mei=Yasumasa kn-aut-name=頓宮廉正 kn-aut-sei=頓宮 kn-aut-mei=廉正 aut-affil-num=2 ORCID= en-aut-name=AjiToshiki en-aut-sei=Aji en-aut-mei=Toshiki kn-aut-name=安治敏樹 kn-aut-sei=安治 kn-aut-mei=敏樹 aut-affil-num=3 ORCID= en-aut-name=IshiiAkira en-aut-sei=Ishii en-aut-mei=Akira kn-aut-name=石井明 kn-aut-sei=石井 kn-aut-mei=明 aut-affil-num=4 ORCID= en-aut-name=NakanishiToshio en-aut-sei=Nakanishi en-aut-mei=Toshio kn-aut-name=中西紀男 kn-aut-sei=中西 kn-aut-mei=紀男 aut-affil-num=5 ORCID= en-aut-name=NakadaHiroshi en-aut-sei=Nakada en-aut-mei=Hiroshi kn-aut-name=仲田浩之 kn-aut-sei=仲田 kn-aut-mei=浩之 aut-affil-num=6 ORCID= en-aut-name=KishimotoNobuyasu en-aut-sei=Kishimoto en-aut-mei=Nobuyasu kn-aut-name=岸本信康 kn-aut-sei=岸本 kn-aut-mei=信康 aut-affil-num=7 ORCID= en-aut-name=NakatsukaTakehisa en-aut-sei=Nakatsuka en-aut-mei=Takehisa kn-aut-name=中塚尊久 kn-aut-sei=中塚 kn-aut-mei=尊久 aut-affil-num=8 ORCID= en-aut-name=KimHitoshi en-aut-sei=Kim en-aut-mei=Hitoshi kn-aut-name=金仁洙 kn-aut-sei=金 kn-aut-mei=仁洙 aut-affil-num=9 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=10 ORCID= en-aut-name=IijimaTakashi en-aut-sei=Iijima en-aut-mei=Takashi kn-aut-name=飯島崇史 kn-aut-sei=飯島 kn-aut-mei=崇史 aut-affil-num=11 ORCID= en-aut-name=KomiyamaHiroshi en-aut-sei=Komiyama en-aut-mei=Hiroshi kn-aut-name=小見山宏 kn-aut-sei=小見山 kn-aut-mei=宏 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=5 en-affil= kn-affil=金田病院内科 affil-num=6 en-affil= kn-affil=金田病院内科 affil-num=7 en-affil= kn-affil=金田病院内科 affil-num=8 en-affil= kn-affil=金田病院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=11 en-affil= kn-affil=中国中央病院外科 affil-num=12 en-affil= kn-affil=小見山外科医院 en-keyword=肝蛭症 kn-keyword=肝蛭症 en-keyword=好酸球増多症 kn-keyword=好酸球増多症 en-keyword=肝膿瘍 kn-keyword=肝膿瘍 en-keyword=ビチオノール kn-keyword=ビチオノール en-keyword=人畜共通感染症 kn-keyword=人畜共通感染症 END start-ver=1.4 cd-journal=joma no-vol=108 cd-vols= no-issue=3-6 article-no= start-page=71 end-page=82 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Prevention of peritoneal dissemination and serosal invasion of digestive tract cancer in an experimental murine model kn-title=癌漿膜浸潤および腹膜播種の防止に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report a novel prophylactic strategy for peritoneal dissemination and serosal invasion of digestive tract cancer in a murine model, in which the murine abdominal wall was compared to the wall of the human digestive tract. Subcutaneous injection of MH-134 cells to the abdominal wall of C3H mice induced tumors on the parietal peritoneum, and eventually caused peritoneal dissemination with time. In this model, the intraperitoneal administration of OK-432, a type of biological response modifier, after tumor implantation significantly inhibited the development of peritoneal dissemination of tumor cells. This effect was more profound in mice with tumors that extended to the peritoneal surface (designated as S1 stage). Histological examination revealed both the remarkable necrosis of tumoral tissue and the formation of a collagen fiber at the edge of the tumor. This antitumoral effect of OK-432 is thought to be mediated by both macrophages and lymphocytes migrated into the peritoneal cavity, because the administration of Carrageenan and anti-lymphocyte serum completely blocked the antitumoral effect of OK-432. en-copyright= kn-copyright= en-aut-name=IijimaTakashi en-aut-sei=Iijima en-aut-mei=Takashi kn-aut-name=飯島崇史 kn-aut-sei=飯島 kn-aut-mei=崇史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=漿膜浸潤 kn-keyword=漿膜浸潤 en-keyword=腹膜播種性転移 kn-keyword=腹膜播種性転移 en-keyword=OK-432 kn-keyword=OK-432 en-keyword=細胞性間質反応 kn-keyword=細胞性間質反応 en-keyword=線維性間質反応 kn-keyword=線維性間質反応 END