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ID 19132
Eprint ID
19132
FullText URL
Thumnail 70_2817.pdf 977 KB
Title Alternative
Anaphylaxis and Oxidation-Reduction Potential Ⅱ: Effect of Antihistamine Drugs on Oxidation-Reduction Potential of Sensitized Animal Organ Tissues in in vitro Anaphylactic Shock
Author
Chikamoto, Koki
Abstract Alternative
The author studied the effect of the antihistamine drugs on the rise of the potential in in vitro anaphylactic shock. The liver slice of the guinea-pig sensitized with the horse serum (0.25 cc) was suspended in Tyrode solution, and then the horse serum was poured into this suspension, thus producing anaphylactic shock. The following antihistamine drugs were used; benadrine (aminoether derivative), pyribenzamine (ethylene-diamine derivative) and anergen (pheno-thiazine derivative). The results are summarized as follows: 1) The rise of potential of the sensitized guinea-pig liver by pouring the horse serum was inhibited by addition of antihistamine drugs. 2) In the inhibition of the rise of potential, benadrine of 3.3×10(-3) -3.3×10(-5) mg / cc was more effective than 3.3 (×) 10 (-6) -3.3×10(-7) mg / cc. 3) For the inhibition of the rise of potential in anaphylactic shock, addition of benabrine 30 to 45 minutes before pouring the serum was more effective than 10 to 20 mintes before pouring. 4) For the inhibition of the rise of potentiol in anaphylactic shock, benadrine and pyribenzamine showed nearly the same effect, but anergen seemed to be somewhat less effective than the other two ones.
Published Date
1958-08-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume70
Issue
issue8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
2817
End Page
2827
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/70/8/70_8_2817/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma