start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=7-2
article-no=
start-page=4283
end-page=4297
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590710
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinico-pathological Studies on the Hepatogenous Myocardosis (Serial Report) Changes on heart sound and electrocardiogram in liver diseases
kn-title=肝性心筋症（Hepatogene Myokardose）の臨床病理学的研究（続報） 肝疾患時の心音並びに心電図の変化について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With the purpose to elucidate changes in heart sound and electrocardiogram in liver diseases, the author studied 85 cases of infectious hepatitis and other liver diseases, and obtained the following results. In the infectious hepatitis irrespective of age or sex, changes such as brachycardia or tachycardia, fall in blood pressures, and abnormality of heart sound can be recongized along with the progress of symptoms, but with exception of fatal hepatitis circulatory insufficiency rarely occurs in any of them. Moreover, these pathological changes are mostly reversible, and in some the murmur of heart sound remains in definitely. As for the findings of electrocardiogram, such findings as a decrease in the height of T-wave, fall in ST, elongation of QT, low potential difference and bloking of the left leg, that determine the damages in the heart muscle can be found in 47.8 per cent of acute hepatitis, in 41.5 per cent of chronic hepatitis, and in 33.4 per cent of liver cirrhosis. Furthermore, judging the liver functions from serum proteins, colloidal reaction, and serum bilirubin values, along with the diminution in the liver functions, the findings that indicate damages of heart muscles can be recognized. Likewise changes in the picture of the liver in autopsy are closely associated with the damage to the heart muscle. Similarly there seems to be a definite relationship between the liver functions and the autonomic nerve system. Again judging from the elctrocardiogram, the murmur of the mitral valve in this diseass consists mainly of hematokinetic problem due to pathological change of the left papillary muscle but not due to the organic change of the mitral valve itself.
en-copyright=
kn-copyright=

en-aut-name=KondoHiroshi
en-aut-sei=Kondo
en-aut-mei=Hiroshi
kn-aut-name=近藤弘
kn-aut-sei=近藤
kn-aut-mei=弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部浜崎病理教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=4
article-no=
start-page=1141
end-page=1152
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Clinical Application of Bismuth Subsalicylate in Treatment of Gastric and Duodenal UlcersReport 3 On the Treatment Conducted for Four Years since 1954 Fukayasu-cho, Fukayasu County, Hiroshima Prefecture
kn-title=胃十二指腸潰瘍に対する次サリチル酸蒼鉛筋肉注射療法の研究 （第3編） 昭和29年以後4年間の治験報告
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=For the past ten years beginning with 1948 we have been using the intramascular injection of bismuth subsalicylate in treatment of 336 cases suffering from gastric and duodenal ulcers. From our experiences we believe that it is most appropriate to start with 0.5 cc of this drug for the initial injection and watching the reaction of patient carefully, to increase the dose by degree until the dose of 1.0 cc is reached. The over-all average time required and the average total dosage used for the entire group were 51.3 days and 6.16 cc respectively. However, looking over the different cases separately, the ones that showed the quickest response to the injection were the cases with duodenal ulcers in that it required on the average 36 days to recover completely and the average dosage of 4.45 cc per person; followed by the cases with ulcers of pars pylorica ventriculi and with ulcers of lesser curvature of stomach in the order mentioned. Moreover, no significant side-effects can be recognized in all the cases treated with this drug during the past ten years.
en-copyright=
kn-copyright=

en-aut-name=KondoHiroshi
en-aut-sei=Kondo
en-aut-mei=Hiroshi
kn-aut-name=近藤弘
kn-aut-sei=近藤
kn-aut-mei=弘
aut-affil-num=1
ORCID=

en-aut-name=MasuokaWataru
en-aut-sei=Masuoka
en-aut-mei=Wataru
kn-aut-name=舛岡亘
kn-aut-sei=舛岡
kn-aut-mei=亘
aut-affil-num=2
ORCID=

en-aut-name=SugaMasaaki
en-aut-sei=Suga
en-aut-mei=Masaaki
kn-aut-name=菅正明
kn-aut-sei=菅
kn-aut-mei=正明
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=広島県深安郡深安町立診療所

affil-num=2
en-affil=
kn-affil=広島県深安郡深安町立診療所

affil-num=3
en-affil=
kn-affil=広島県深安郡深安町立診療所
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=5
article-no=
start-page=255
end-page=269
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19560531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Intermuscular Injection of Bismuth Subsalicylate as the Treatment for Gastric and Duodenal Ulcers Part One Clinical Observations on the Intermucular Injection of Bismuth Subsali cylate in Oil for Gastric and Duodenal Ulcers, and Pathological Findings of the Stomach that Required an Excision
kn-title=胃十二指腸潰瘍に対する次サリチル酸蒼鉛筋肉注射療法の研究（第一編）Bismuth Subsalicylate (in oil) の胃十二指腸潰瘍に対する筋注療法の臨床的観察と該療法中切除を要したる胃の病理学的所見
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author in 1947 had an opportunity to come across a patient suffering from the ulcer of stomach having signs suggestive of gastric syphilis and by giving intermuscular injection treatment of bismuth subsalicylate in oil had obtained quite favorable results. During the treatment it was discovered that the conditions of the patient had turned for the better about the time when bismuth deposited on the gum of the Patient. So it was thought that one of course of improvement could be attributed to swallowing bismuth secreted into saliva. Consequently this is not same as the medical effects of the usual bismuth treatment. Thereupon, the author employed the intermuscular injection treatment of bismuth instead of the usual oral administration of bismuth to the patients with gastric and duodenal ulcers, expecting and relying on the favorable result of swallowing down bismuth secreted into saliva. During six years 118 cases of gastric and duodenal ulcers have been treated with the same method and obtained relatively satisfactory results without any notable complications. Further in all six incurable cases their extirpated stomach was opened and examined under the direction of Prof. Hamazaki, and each one of them had such lesion as perforated ulcer, stomach cancer, or stenosis of the pylorus, everyone of which requires a surgical operation. The author entertains an idea that in the intermuscular treatment of bismuth subsalicylate in oil bismuth is secrected into saliva. By various tests and experiments the author found out that the secretion of bismuth continual for six years in the longer cases, and it has given unusually favorable effects for gastric ulcer. However, this latter point is going to be reported in Part Two.
en-copyright=
kn-copyright=

en-aut-name=KondoHiroshi
en-aut-sei=Kondo
en-aut-mei=Hiroshi
kn-aut-name=近藤弘
kn-aut-sei=近藤
kn-aut-mei=弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部浜崎病理教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=5
article-no=
start-page=271
end-page=282
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19560531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Treatement for Gastric and Duodenal Ulcer by the Intramuscular Injection of Bismuth SubsaliylatePart, Ⅱ Observations on the Intramuscular Injection of Bismuth Subsalicylate in Oil
kn-title=胃十二指腸潰瘍に対する次サリチル酸蒼鉛筋肉注射療法の研究（第二編）筋注された次サリチル酸蒼鉛剤の運命に関する探求
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In part, Ⅱ the author investigated the histological staining possibilities of various bismuth compounds and then, by the intramuscular injections, verified the distribution of bismuth in the tissues of the stomach and of the duodenum both in men and rabbits. It was noticed that the conditions of the recipients (men and rabbits) received the injection had turned for the better with the continuous decrease in the acidity of the gastric juice. The cause of these changes was histopathologically found to be due not only to the direct action of Bismuth contained saliva on the ulcer but also to the chemical reaction between bismuth and gartric acid, and thus apparently to a beneficial effect of bismuth on the function of the stomach tissue-cells. By this experiment, it is considered that water-soluble bismuth tartarate which absorbed or secreted quite rapidly is rather harmful than the more slowly absorbed and secreted one like oil-soluble bismuth subsalicylate. So I believe that the latter is more suitable for the treatment of the gastric ulcers. Moreover, the chemical quantitative value of bismuth in the tissues of man suggests that this substance (bismuth subsalicylate) will be slowly and protractedly absorbed and secreted, and consequently acts on the gastric tissue for a considerably long period. The present investigation has proved that intramuscular injection of bismuth subsalicylate will act gradually for a long time and that, when once administered, bismuth subsalicylate is continuously effective for the gastric and duodenal ulcers.
en-copyright=
kn-copyright=

en-aut-name=KondoHiroshi
en-aut-sei=Kondo
en-aut-mei=Hiroshi
kn-aut-name=近藤弘
kn-aut-sei=近藤
kn-aut-mei=弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部浜崎病理学教室
END