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ID 32840
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Author
Kawasoe, Chiaki
Sato, Katsunori
Abstract

Changes in norepinephrine-induced transient contractions in Ca2+-deficient solution were investigated in the aortic smooth muscles of diabetic ALS (alloxan-induced diabetes susceptible) mice. The transient contractions in diabetic mice were significantly larger than those in normal mice. The longer incubation of the muscle preparations in Ca2+-deficient solution made the transient contractions smaller, probably due to the leakage and decrease in norepinephrine-releasable stored Ca2+. The rate of this reduction in contraction was slower in diabetic mice. These results suggest that the leakage of intracellular stored Ca2+ caused by extracellular Ca2+ deficiency is attenuated in diabetic mice, contributing to enhanced norepinephrine-induced transient contractions.

Keywords
diabetes mellitus
vascular smooth muscle
norepinephrine
Amo Type
Article
Published Date
2003-02
Publication Title
Acta Medica Okayama
Volume
volume57
Issue
issue1
Publisher
Okayama University Medical School
Start Page
45
End Page
48
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT