start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=1 article-no= start-page=29 end-page=33 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Mesalazine suppositories and their clinical application kn-title=メサラジン坐薬調製の工夫と臨床経験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ulcerative proctitis (UP) is a prevalent condition associated with increased morbidity, and topical mesalazine (5-aminosalicylic acid [5-ASA]) is known to inhibit the inflammatory processes in UP. We successfully devised mesalazine suppositories, in which 250mg mesalazine was equally distributed and remained stable for at least 2 weeks. We evaluated the effect of using mesalazine suppositories twice a day (BID) on two UP patients. The results demonstrated that mesalazine suppositories were efficacious, well tolerated and safe for the long-term maintenance of UP remission. en-copyright= kn-copyright= en-aut-name=FunagakureKeiko en-aut-sei=Funagakure en-aut-mei=Keiko kn-aut-name=船隠恵子 kn-aut-sei=船隠 kn-aut-mei=恵子 aut-affil-num=1 ORCID= en-aut-name=HoritaSyuzi en-aut-sei=Horita en-aut-mei=Syuzi kn-aut-name=堀田修次 kn-aut-sei=堀田 kn-aut-mei=修次 aut-affil-num=2 ORCID= en-aut-name=HamaokaTerutaka en-aut-sei=Hamaoka en-aut-mei=Terutaka kn-aut-name=濱岡照隆 kn-aut-sei=濱岡 kn-aut-mei=照隆 aut-affil-num=3 ORCID= en-aut-name=TasakaTakeshi en-aut-sei=Tasaka en-aut-mei=Takeshi kn-aut-name=田阪武志 kn-aut-sei=田阪 kn-aut-mei=武志 aut-affil-num=4 ORCID= en-aut-name=TatibanaHiroshi en-aut-sei=Tatibana en-aut-mei=Hiroshi kn-aut-name=立花広志 kn-aut-sei=立花 kn-aut-mei=広志 aut-affil-num=5 ORCID= en-aut-name=MurakamiTakako en-aut-sei=Murakami en-aut-mei=Takako kn-aut-name=村上敬子 kn-aut-sei=村上 kn-aut-mei=敬子 aut-affil-num=6 ORCID= en-aut-name=ToyokawaTatuya en-aut-sei=Toyokawa en-aut-mei=Tatuya kn-aut-name=豊川達也 kn-aut-sei=豊川 kn-aut-mei=達也 aut-affil-num=7 ORCID= en-aut-name=SatoEiji en-aut-sei=Sato en-aut-mei=Eiji kn-aut-name=佐藤英治 kn-aut-sei=佐藤 kn-aut-mei=英治 aut-affil-num=8 ORCID= en-aut-name=TomodaJun en-aut-sei=Tomoda en-aut-mei=Jun kn-aut-name=友田純 kn-aut-sei=友田 kn-aut-mei=純 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　薬剤科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　薬剤科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　薬剤科 affil-num=4 en-affil= kn-affil=国立病院機構福山医療センター　薬剤科 affil-num=5 en-affil= kn-affil=国立病院機構福山医療センター　薬剤科 affil-num=6 en-affil= kn-affil=国立病院機構福山医療センター　内科 affil-num=7 en-affil= kn-affil=国立病院機構福山医療センター　内科 affil-num=8 en-affil= kn-affil=福山大学薬学部 affil-num=9 en-affil= kn-affil=国立病院機構福山医療センター　内科 en-keyword=メサラジン坐薬（mesalazine suppositories） kn-keyword=メサラジン坐薬（mesalazine suppositories） en-keyword=潰瘍性大腸炎直腸型（ulcerative proctitis） kn-keyword=潰瘍性大腸炎直腸型（ulcerative proctitis） END