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ID 14774
Eprint ID
14774
FullText URL
Title Alternative
A case of Parkinson's disease associated with bromocriptine - induced leukopenia and throm-bocytopenia
Author
Mifune, Takashi
Mitsunobu, Fumihiro Kaken ID researchmap
Okamoto, Makoto
Nishida, Norikazu
Tsugeno, Hirofumi
Hosaki, Yasuhiro
Yokoi, Tadashi
Tanizaki, Yoshiro
Niiya, Kenji
Abstract
症例は67歳,女性。以前からパーキンソン病にて加療されていたが,リハビリテーション目的で当院入院した.入院時白血球数,血小板数正常であったが,bromocriptine投与開始後白血球減少,血小板減少を認めた.薬剤性白血球減少症及び血小板減少症を疑い, bromocriptine投与中止するとともにfilgrastim投与により,白血球減少,血小板減少は改善した。誘発試験施行し白血球減少を認めた。Bromocriptineによる白血球減少症,血小板減少症の報告は少なく,我々の検索しえた範円内では本症例を含めて2例のみであった。Bromocriptineには安全性や神経保護作用に関して多くのデータの蓄積があるが,安全性に十分な注意が必要であると考えられた。
Abstract Alternative
A 67-year-old woman had been treated for Parkinson's disease before. She was admitted to our hospital for rehabilitation. On admission the leukocyte count and the platelet count were normal. But routine blood studies began to show leukopenia and thrombocytopenia after administration of bromocriptine. We suspected drug-induced leukopenia and thrombocytopenia. After stopping bromocriptine therapy and administration of filgrastim, the leukopenia and the thrombocytopenia disappeared. She developed leukopenia again after provocation test with bromocriptine. There are few reports about bromocriptine-induced leukopenia and thrombocytopenia. To our knowledge, only 2 cases (including our case) of bromocriptine-induced leukopenia have been reported. Bromocriptine has much data about safety and neuroprotection. However, we must take care of the safety fully.
Keywords
パーキンソン病 (Parkinson's disease)
ブロモクリプチン (Bromocriptine)
白球血減少症 (Leukopenia)
血小板減少症 (Thrombocytopenia)
フィルグラスチム (Filgrastim)
Published Date
2003-02-01
Publication Title
岡大三朝医療センター研究報告
Publication Title Alternative
Annual reports of Misasa Medical Center, Okayama University Medical School / Misasa Medical Center, Okayama University Medical School
Volume
volume73
Publisher
岡山大学医学部附属病院三朝医療センター
Publisher Alternative
Okayama University Medical School / Misasa Medical Center, Okayama University Medical School
Start Page
84
End Page
87
ISSN
1348-1258
NCID
AA11840279
Content Type
Departmental Bulletin Paper
language
日本語
File Version
publisher
Refereed
False
Eprints Journal Name
mmc