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ID 19318
Eprint ID
19318
FullText URL
Thumnail 70_4111.pdf 6.31 MB
Title Alternative
Studies on Benzene Poisoning Part 2 The Influence of Inhalated Benzene on Blood Picture, Ethereal Sulfate Ratio and Phenol in the Urine and Clinical Symotoms in Rabbits
Author
Sugahara, Kiyoshi
Abstract
For the purpose of inducing benzene poisoning in the rabbits by inhalation of benzene, the author deviced a new type of generator and inspirator of benzene gas to be maintained at a constant concentration and performed experiments of benzene inhalation with rabbits and guinea-pigs; and obtained the following results: 1. In the benzene inhalation with the rabbits, at the concentration of 15,000 p.p.m. or more, test rabbits died within several hours, and at the concentration of 10.000 p.p.m., they died within 3 weeks, and at 5.000 p.p.m. in a month. However at the concentration of 2,000 p.p.m. they all survived. 2. In the case of the guinea-pigs benzene inhalated was exhalated again almost completely within 5 hours after cessation of the inhalation. Hematological changes: 1. In general, at all concentrations, the red cell count, leucocyte count and hemoglobin content temporarily increased immediately after inhalation, but thereafter they decreased by degrees in the course of repeated inhalation. As for the leucocyte series, pseudo-eosinophil leucocyte had obviously sustaind effect on both relative percentage and absolute counts, and also the leftward nuclear shift was observed. 2. The reticulocyte count also by inhalation brought about an obvious increase temporarily, but on the other hand, it tended to increase in the last stage. 3. On the smear preparation, staining of proper granules of pseudo-eosinophil leucocytes grew poor by degrees, and when benzene was inhaled at the concentration of 5,000 p.p.m. or more, there appeared toxic granules, and violent anisocytosis and poikilocytosis was observed in the last stage.
Published Date
1958-11-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume70
Issue
issue11
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
4111
End Page
4127
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/70/11/70_11_4111/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma