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ID 19315
Eprint ID
19315
FullText URL
Thumnail 70_4099.pdf 5.24 MB
Title Alternative
Studies on Benzene Poisoning Part 1 Studies on Detoxication and Excretion of Administrated
Author
Sugahara, Kiyoshi
Abstract
As a link in the studies on benzene poisoning, the butanone method for the microquantitative analysis of benzene in the air has been investigated, and also various conditions leading to the maximum development of the colour have been determined; and a situation of elimination of unchanged benzene, the ratio of ethereal sulfate to total sulfate and phenol in the urine after the rabbits receiving benzene have been studied. The results are as follows: 1. As for the concentration ethanol at 1-2 per cent, NaOH at 0.005-0.008 per cent and H(2)O at below 0.5 per cent proved to be optimal on the development of the colour by the butanone method. 2. After the administration of 200-500 mg benzene per Kg. body weight, benzene concentration in the exhaled air increased rapidly, and reached the maximum 2 hours after oral administration and intra peritoneal injection. Thereafter it decreased rapidly and became almost zero 15 hours later, while in the case of subctaneous injection, it reached its maximum 3 hours afterward, and thereafter, though gradually, the elimination continued over 24 hours after administration. 3. Ethereal sulfate ratio and phenol in the urine reached the maximum 24 hours after receiving benzene, but they returned to the normal level 48 hours afterward. 4. In the cases of 0.2-1.0 g/kg of benzene by various method, the ratio of eliminated benzene to administrated one obtained so far are as follows: as elimination unchanged 43.5-78% as ethereal sulfate 2.9-18% as phenol 3.2-16.7% as a whole, 73.5-83.9% has been eliminated.
Published Date
1958-11-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume70
Issue
issue11
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
4099
End Page
4110
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/70/11/70_11_4099/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma