JaLCDOI 10.18926/14906
Title Alternative 気管支喘息患者における肺機能とHRCT上のlow attenuation areaに対する喫煙の影響
FullText URL 071_029_035.pdf
Author Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Takada, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro|
Abstract The influence of smoking on pulmonary function and emphysematous changes of the lung (percentage of attenuation area < -950 HU (% LAA) on high resolution computed tomography (HRCT) was examined in 49 patients with bronchial asthma. 1. In patients with asthma, the % residual volume (RV) in many nonsmokers was less than 129%, in contrast, the % RV in many smokers was between 130% and 189% , which was higher than that in nonsmokers. 2. Significant correlations between % RV and 96LAA value, and between % RV and CT number were observed both in nonsmokers and smokers with asthma, in which as % RV more increased, % LAA value was larger, and CT number was lower. 3. % DLco value was lower in smoking patients with asthma, whose % RV was between 130% and 189% and larger than 190% , however, the % DLco value did not change in nonsmoking patients despite of higher valure in % RV. 4. A significant correlation was also observed between % FEV1.0 value and % RV both in smoking and nonsmoking patients with asthma; as % RV value more increased, % FEV1.0 value was lower. 5. Any correlation between % FVC value and % RV was not observed. These results suggest that smoking affects the % LAA of the lung on HRCT and % DLco in patients with asthma.
Abstract Alternative 気管支喘息49例を対象に、肺機能およびHigh resolution computed tomography(HRCT)上のLow attenuation are (LAA) <-950HUで示される肺気腫様変化に及ぼす喫煙の影響について検討した。  1.気管支喘息患者のうち、非喫煙例では% 残気量(% RV)は多くの症例(65.6% )で129% 以下であったが、一方喫煙症例では130% から189% を示す症例が最も多く見られた(60.0% )。非喫煙例および喫煙例いずれにおいても、 2.% RVと% LAA、% RVとCT number 間に有意の相関が見られた: % RVが上昇するにつれて、% LAA値は増加し、CT numberは低下する傾向が見られた。  3.喫煙例では、% RVが130-189% あるいは190% 以上の症例で、% DLco値 が明かに低値を示す症例が見られたが、非喫煙症例では% RVが高い値を示しても% DLcoの低下はみられなかった。  4.喫煙例、非喫煙例いずれにおいても、% FEV1.0倍と% RV値の問には有意の相関が見られ、% RV値が上昇するにつれて、% FEV1.0値は低下する傾向が見られた。  5.% FVCと% RVの問には相関は見られなかった。以上の結果より、喫煙は気管支喘息患者のHRCT上の% LAAおよび% DLcoに影響を与えることが示唆された。
Keywords asthma smoking % LAA of the lungs FEV1.0 DLco
Publication Title 岡大三朝分院研究報告
Published Date 2001-02-01
Volume volume71
Start Page 29
End Page 35
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308294
JaLCDOI 10.18926/14975
Title Alternative 気管支喘息におけるHRCTによるLow attenuation area(LAA)と平均CT numberとの関連
FullText URL 068_015_021.pdf
Author Mitsunobu, Fumihiro| Ashida, Kozo| Mifune, Takashi| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Okamoto, Makoto| Iwagaki, Naofumi| Yamamoto, Kazuhiko| Tanizaki, Yoshiro| Nakai, Mutsuo| Akiyama, Tsuneo| Hasegawa, Harumi|
Abstract The maximal percent low attenuation area < -950 HU (% LAA) among three anatomic lung levels on high resolution computed tomography (HRCT) was examined in patients with asthma, classified by the degree of % LAA, in relation to the mean CT number, % FVC of the predicted value, and FEV 1/FVC (FEV1%). 1 . The mean CT number was closely related to the degree of % LAA of the lungs. The mean CT number was significantly lower in patients with high % LAA (mean CT number-915.3HU, % LAA 37.6%) than in those with low % LAA (-852.9HU, 4.7%). 2. The FEV1% value was significantly lower in patients with high % LAA (47.8%) than in those with low % LAA (62.2%)(p<0.05). The % FVC value was also significantly lower in patients with high % LAA (77.1%) compared to the value in those with low % LAA (101.2%). The results suggest that a large volume of LAA<-950HU of the lungs can be observed in patients with asthma, and the % LAA is closely correlated with mean CT number and the values of FEV1% and % FVC.
Abstract Alternative HRCT (high resolution computed tomography)により,-950HU以下のlow attenuation area(LAA)を3つの高さの肺野レベルで観察し,そのなかの最も高い値をmaximal% LAAとして表し,この値と平均CT number, % FVCおよびFEV1.0%の値と比較検討した。1.平均CT numberは,maximal% LAAと密接な関連を示した。そして,平均CT numberは,% LAAが低い症例(% LAA :4.7%, mean CT number:-852.9HU)に比べ,% LAAが高い症例(% LAA :37.6%, mean CT number:-915.3HU)において低い傾向が見られた。2.FEV1.0%値は,% LAA値が低い症例(62.2%)に比べ% LAA値が高い症例(47.8%)において有意に低い値を示した(P<0.05)。% FVC値も同様% LAA値が低い症例(101.2%)に比べ高い症例(77.1%)で低い値を示したが両群間に有意の差は見られなかった。これらの結果より,気管支喘息においも,HRCT上肺野で-950HU以下のLow attenuation area(LAA)を示す症例が見られること,そして,% LAAは,mean CT number,FEV1.0%や% FVC値とある程度関連していることが示唆された。
Keywords bronchial asthma % LAA mean CT number FEV1 FVC
Publication Title 岡大三朝分院研究報告
Published Date 1997-12
Volume volume68
Start Page 15
End Page 21
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308351
JaLCDOI 10.18926/14907
Title Alternative 気管支喘息症例における末梢血白血球のロイコトリエンC4産生能とロイコトリエン受容体括抗薬プランルカストの効果に関する検討
FullText URL 071_036_041.pdf
Author Mifune, Takashi| Takada, Shingo| Okamoto, Makoto| Tsugeno, Hirofumi| Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tanizaki, Yoshiro| Harada, Mine|
Abstract The correlation between the efficacy of 4-weeks administration with pranlukast, leukotriene receptor antagonist, and LTs generation by peripheral leukocytes were evaluated in 18 patients with mild-persistent asthma. The efficacy of pranlukast administration was assessed by symptom, morning PEF and pulmonary function. Pranlukast were effective in 12/18(67%) patients. In those patients, LTC4 generation before pranlukast administration was significantly high, compared with that in pranlukast-ineffective patients. LTC4 generation decreased after 4-weeks administration with pranlukast in effective patients. In ineffective patients, however, LTC4 generation increased after 4-weeks administration. LTB4 had shown no significant difference between effective and ineffective patients before administration, and LTB4 decreased after 4-weeks in both groups. Proport ion of peripheral eosinophi Is in effective patients were higher than that in ineffective patients, however not significant. After 4-weeks, proportion of eosinophi Is was decreased in effective patients and increased in ineffective patients. These findings suggest that pranlukast is effective for patients with high LTC4 generation and has the effect to suppress the accumulation of eosinophils in such patients.
Abstract Alternative 軽症気管支喘息18例にロイコトリエン受容体桔抗薬プランルカストを4週間投与し,その効果と末梢血白血球からのLTC4,LTB4産生能の関係を検討した.プランルカストの効果は臨床症状,起床時ピークフロー値,肺機能の変化によって判定し,効果群,非効果群の2群に分類した.18例中12例(67%)の症例がプランルカスト投与により,臨床症状の軽減,ピークフロー値の増加,肺機能の改善が認められた.効果群におけるプランルカスト投与前のLTC4値は,非効果群のLTC4値に比較して有意に高値であった.4週間の投与後には 効果群ではLTC4値は減少し,非効果群では増加した.両群のLTB4値はプランルカスト投与前で有意な差は認められず,投与後には両群で減少した.投与前の好酸球分画は,効果群において非効果群に比べ高値であったが,有意な差は認められなかった.4週間の投与後,効果群においては好酸球は減少し,非効果群においては増加した.以上の結果より,プランルカストは末梢血白血球のLTC4産生能が高い症例において効果的であり,好酸球集積を抑制する作用を有すると考えられる.
Keywords bronchial asthma pranlukast leukotriene receptor antagonist LTC4
Publication Title 岡大三朝分院研究報告
Published Date 2001-02-01
Volume volume71
Start Page 36
End Page 41
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308269
JaLCDOI 10.18926/14955
Title Alternative 気管支喘息患者における努力肺活量(% FVC)の低下と気道炎症ならびに臨床病型との関連
FullText URL 069_028_034.pdf
Author Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo|
Abstract Clinical features of asthmatics with a low % FVC (<80%) were studied in relation to airway inflammation and clinical asthma types. 1. Twenty four (75.0%) of the 32 subjects with a low % FVC had steroid-dependent intractable asthma. 2. A significant association between % FVC value and clinical asthma type was found. The value of % FVC was significantly lower in subjects with type II asthma (bronchiolar obstruction), in which significantly decreased proportion of lymphocytes,and significantly increased proportion of neutrophils in bronchoalveolar lavage (BAL) fluid were observed, than in those with type la-1 (simple bronchoconstriction) with (P<0.001) and without glucocorticoid therapy (P<0.02). 3. The % FVC value was significantly improved after treatment in type lb (hypersecretion) with BAL eosinophilia, but not in those with type II with BAL neutrophilia. These results demonstrate that marked decrease of % FVC in patients with asthma correlated with airway inflammation, and that airway reversibility by medication is very low in patients with type II asthma.
Abstract Alternative 努力肺活量(% FVC)低値を示す気管支喘息の臨床病態を明らかにするために気道炎症ならびに臨床病型との関連について検討を行った。% FVCが80%未満の気管支喘息患者32名を対象として,スパイロメトリー,気管支肺胞洗浄(BAL)を施行し,臨床病態を解析し,治療効果の評価を行なった。1.対象中24名(75%)の患者がステロイド依存性重症難治性喘息であった。2.細気管支閉塞型喘息患者において,% FVC値の有意の低下が認められ,BAL液中のリンパ球の減少と好中球の増加が認められた。3.FVC値,FEV1.0億の治療による改善は,BAL液中好酸球の増加を示す過分泌型喘息においては認められが,BAL液中好中球の増加を示す細気管支閉塞型喘息においては認められなかった。 以上より喘息患者における% FVC値の低下は気道炎症と関連しており,細気管支閉塞型喘息における治療による可逆性は著しく低下していることが示唆された。
Keywords ventilatory function FEV1.0 bronchoalveolar lavage bronchial reversibility
Publication Title 岡大三朝分院研究報告
Published Date 1998-12
Volume volume69
Start Page 28
End Page 34
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308252
JaLCDOI 10.18926/14979
Title Alternative 気管支喘息症例における臨床的特徴と鼻腔・副鼻腔のCT所見の関連について
FullText URL 068_034_040.pdf
Author Mifune, Takashi| Yamamoto, Kazuhiko| Iwagaki, Naofumi| Okamoto, Makoto| Tsugeno, Hirofumi| Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tanizaki, Yoshiro| Tada, Shinya| Harada, Mine|
Abstract Extent of nasal and maxillary mucosa lesion was estimated in 26 asthmatics using computed tomographic scan in relation to clinical features of the disease. 1. No significant differences were present in nasal mucosal thickening between atopic and non-atopic subjects. No significant differences were also present in occupancy rate of mucosa in maxillary sinuses between the two asthma types. 2. Nasal mucosal thickening was not significant different between subjects with steroid-dependent intractable asthma (SDIA) and those without SDIA. Maxillary mucosal lesions were more extensive in subjects with SDIA than in those without SOIA. However, no significant differences were observed in occupancy rate between the two types. 3. No significant differences were observed in nasal mucosal thickenings between in subjects with and without aspirin-induced asthma (AlA). Although maxillary mucosa lesion in subjects with AlA was more extensive than that in those without AlA, the differences was not significant. 4. There was not any correlation between nasal mucosal thickening and amount of expectoration per day. However, significant differences were observed in maxillary sinus lesion between subjects with less amount (<50mℓ/day) and those with large amount of expectoration (100mℓ/day≦)(p<0.002), and between subjects with moderate amount (50-99mℓ/ day) and those with large amount of expectoration (p<0.002). The results might suggest that in asthmatics with large amount of expectoration, sinus diseases affect pathophysiology of asthma, and asthmatics with large amount of expectoration should have therapy for sinus disease to improve asthmatic status.
Abstract Alternative 気管支喘息26症例において喘息の臨床的特徴と,鼻腔・上顎洞のCT所見の関連について検討を加えた。1.鼻腔粘膜肥厚はアトピー症例,非アトピー症例間で有意な差は認められなかった。上顎洞における粘膜肥厚比率(1slice上の上顎洞面積に対し,上顎洞粘膜が占める割合)も,アトピー・非アトピーで差は認められなかった。2.ステロイド依存群・非依存群においても,鼻腔粘膜肥厚・上顎洞粘膜肥厚に有意な差は認められなかった。3.アスピリン喘息症例においては,非アスピリン喘息症例に比べ,上顎洞粘膜肥厚が顕著であっ たが有意ではなかった。鼻腔粘膜肥厚は2群間で差は認められなかった。4.発作時の一日喀痰量との関連では一日喀痰量が100mℓ以上の症例群では,喀痰量が50mℓ以下の群・50-100mℓの群に比較して有意に上顎洞粘膜肥厚比率が高値を示した。鼻腔粘膜比率に関しては3群間で有意な差を認めなかった。以上の結果から,喀痰量の多い気管支喘息症例では,その病態に副鼻腔病変が影響を及ぼしている可能性が考えられ,副鼻腔病変に対する治療により,気管支喘息が改善する可能性が考えられた。
Keywords bronchial asthma sinusitis nasal disease CT scan expectoration
Publication Title 岡大三朝分院研究報告
Published Date 1997-12
Volume volume68
Start Page 34
End Page 40
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308538
Author Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Hamada, Masanori| Iwagaki, Naofumi| Fujii, Makoto| Takata, Shingo| Tanizaki, Yoshiro|
Published Date 2004-12-01
Publication Title 岡大三朝医療センター研究報告
Volume volume75
Content Type Departmental Bulletin Paper
JaLCDOI 10.18926/14998
Title Alternative BAL液中好中球増加をともなわないⅡ型喘息について
FullText URL 067_001_007.pdf
Author Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Tsuji, Takao|
Abstract Clinical features of asthma patients with bronchiolar obstruction (type Ⅱ asthma) were studied in relation to the proportion of neutrophils in bronchoalveolar lavage (BAL) fluid. Of 13 subjects studied, 7 were accompanied with BAL neutrophilia (53.5%) (BALn(+)) and 6 were without BAL neutrophilia (3.5%) (BALn(-)). 1. The mean age was higher in BALn(-) (66.0 years) than in BALn(+) patients (55.0 years). 2. Bronchial reactivity to methacholine was slightly higher in BALn(-) patients than in those with BALn(+). 3. The value of FEV1.0% was significantly lower in BALn(+) patints than in those with BALn(-) (p<0.01). 4. The proportion of BAL lymphocytes was signicantly more decreased in BALn(+) patients compared to the proportion in those with BALn(-) (p<0.001). 5. the values of serum IgG, IgA, and IgM were not significantly different between BALn(+) and BALn(-) patients, however, the value of IgG was more decreased in BALn(+) patients than in those with BALn(-). These results suggest that two kinds of type Ⅱ asthma ; one is with BAL neutrophilia related to suppressed immunity, and another is without BAL neutrophilia in part due to aging.
Abstract Alternative 細気管支閉塞型(Ⅱ型)喘息の臨床的特徴が,BAL液中の好中球頻度との関連のもとに検討された。対象13例のうち,7例がBAL液中好中球増加(平均好中球頻度;53.5%)をともなう症例(BALn(+))で,残りの6例はBAL液中好中球増加 をともなわない(3.5%)症例(BALn(-))であった。1.平均年齢は,BALn(+)症例(55.0才)に比べ,BALn(-)症例(66.0才)でより高い傾向が見られた。2.メサコリンに対する気道過敏性は,BALn(+)症例に比べBALn(-)症例でやや高い傾向が見られたが,両者間に有意の差は見られなかった。3.FEV1.0%値は,BALn(-)症例に比べBALn(+)症例で有意に低い値を示した(P<0.05)。4.BAL液中リンパ球頻度はBALn(+)症例でBALn(-)症例に比べ有意に低い値を示した(P<0.001)。5.血清IgG,IgAおよびIgM値には両者間に有意の差は見られなかったが,IgG値はBALn(+)症例でより低い傾向が見られた。これらの結果より,Ⅱ型喘息にはBAL液中好中球増加を示す症例と示さない症例の2種類があること,そして前者は免疫能の低下と,そして後者は加齢とある程度の関連があることが示唆された。
Keywords 気管支喘息 (Bronchial asthma) 細気管支閉塞 (Bronchiolar obstruction) BAL好中球 (BAL neutrophilia) 免疫能低下 (Suppressed immunity) 加齢 (Aging)
Publication Title 岡大三朝分院研究報告
Published Date 1996-11
Volume volume67
Start Page 1
End Page 7
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308171
JaLCDOI 10.18926/14999
Title Alternative 肺活量(FVC)低値を示す気管支喘息の臨床的特徴
FullText URL 067_008_013.pdf
Author Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo|
Abstract Clinical features of asthma patients with a low % FVC (<75%) were studied in relation to clinical asthma type and disease severity. 1. The value of % FVC was not related to patient age. 2. A significant association between % FVC value and clinical asthma type was found. The value of % FVC was significantly lower in subjects with type Ⅱ asthma (bronchiolar obstruction) than in those with type Ia-1 and type Ia-2 (simple bronchoconstriction) (p<0.001). 3. % FVC value significantly correlated with disease severity. The value in the subjects tended to decrease as their asthma conditions were more severe. 4. The % FVC value in the subjects was improved after treatment (complex spa therapy). These results demonstrate that a significant correlation is present between low % FVC and disease severity in asthma patients with a low % FVC.
Abstract Alternative % 肺活量が75%以下の低値を示す気管支喘息について,その臨床的特徴を,臨床病型や重症度との関連のもとに検討した。1.% 肺活量と年齢との間には関連は見られなかった。2.% 肺活量と臨床病型との問には有意の関連が見られ,Ⅱ型喘息(細気管支閉塞型)における% 肺活量は,Ia-1型やIa-2型などの単純性気管支攣縮型に比べ,有意に低い値を示した。3.% 肺活量はまた喘息の重症度と有意の関連を示した。これらの症例では,喘息の重症度が増すにつれて,% 肺活量は減少する傾向が見られた。4.これら症例の低値を示す% 肺活量は,治療(複合温泉療法)により改善される傾向が見られた。以上の結果より,これらの症例(% 肺活量が75%以下)では,% 肺活量と喘息の重症度との間にある程度の関連があることが明らかになった。
Keywords % FVC低値 (Low % FVC) 気管支喘息 (Bronchial asthma) 臨床病型 (Clinical asthma type) 重症度 (asthma severity) 温泉療法 (Spa therapy)
Publication Title 岡大三朝分院研究報告
Published Date 1996-11
Volume volume67
Start Page 8
End Page 13
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308511
Author Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori| Tanizaki, Yoshiro|
Published Date 2004-02-01
Publication Title 岡大三朝医療センター研究報告
Volume volume74
Content Type Departmental Bulletin Paper
Author Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori| Tanizaki, Yoshiro|
Published Date 2004-02-01
Publication Title 岡大三朝医療センター研究報告
Volume volume74
Content Type Departmental Bulletin Paper
Author Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Hamada, Masanori| Iwagaki, Naofumi| Fujii, Makoto| Takata, Shingo| Tanizaki, Yoshiro|
Published Date 2004-12-01
Publication Title 岡大三朝医療センター研究報告
Volume volume75
Content Type Departmental Bulletin Paper
JaLCDOI 10.18926/14935
Title Alternative A Case of Recurrent Churg-Strauss Syndrome Associated with Bronchial Asthma
FullText URL 070_061_066.pdf
Author Harada, Seishi| Tsugeno, Hirofumi| Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Okamoto, Makoto| Takata, Shingo| Yamamoto, Toshio| Tanizaki, Yoshiro|
Abstract 入院中にChurg-Strauss症候群の再燃を来した症例を報告した。症例は気管支喘息を有する73歳の女性で,持続する両下肢の知覚障害を主訴に当院に入院した。入院2週頃より微熱,下腹部不快感が続き右下肢のdrop foot,下血を呈した。末梢血では著明な好酸球増多を認め,内視鏡検査で直腸潰瘍を認めた。3年前の両下肢の知覚障害出現時にも同様の症状を経験しており,Churg-Strauss症候群の再燃と診断し,ステロイド治療を開始することにより新たな後遺症を残すことなく寛解に至った。Churg-Strauss症候群の発症・再燃の機序を考える上で貴重な症例と考え,文献的考察を加え報告する。
Abstract Alternative A recurrent case of Churg-Strauss syndrome (CSS) associated with bronchial asthma is reported. A 73-year-old woman with bronchial asthma was admitted to our hospital because of persistent sensory disturbance of the bilateral lower limbs. About 2 weeks or more after admission, slight fever and an unpleasant sensation in the lower abdomen appeared and continued. Several days later, drop foot and melena developed. The eosinophil count was markedly increased and the endoscopic examination revealed rectal ulcers. Since the patient had a same experience of these symptoms three years ago, the recurrence of CSS was strongly suggested. Immediately after steroid treatment was started, these newly developed symptoms were relieved with no segulae. We reported the present case, which may be useful for clarifying the onset of CSS, with a review of the literature.
Keywords Churg-Strauss症候群 (Churg-Strauss syndrome) アレルギー性肉芽腫性血管炎 (allergic granulomatous angiitis) 血管炎症候群 (vasculitis syndrome) 気管支喘息 (bronchial asthma) 好酸球増多 (eosinophilia)
Publication Title 岡大三朝分院研究報告
Published Date 1999-12
Volume volume70
Start Page 61
End Page 66
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002308532
Author Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori| Tanizaki, Yoshiro|
Published Date 2004-02-01
Publication Title 岡大三朝医療センター研究報告
Volume volume74
Content Type Departmental Bulletin Paper
JaLCDOI 10.18926/15002
Title Alternative Ia型(単純気管支れん縮型)喘息における気道過敏性について…年齢および気管支肺胞洗浄液中の細胞成分との関連について
FullText URL 067_028_034.pdf
Author Ashida, Kozo| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo|
Abstract Bronchial hyperresponsiveness was examined in relation to age, ventilatory function, and the proportion of bronchoalveolar lavage (BAL) cells in 39 patients with type Ia asthma (simple bronchoconstriction) (25 with type Ia-1 and 14 with type Ia-2), classified by clinical symptoms. 1. The proportion of BAL eosinophils was significantly higher in type Ia-2 than that in type Ia-1 asthma patients. 2. Bronchial reactivity to methacholine was not different between type Ia-1 and type Ia-2 asthma patients. 3. Bronchial hyperreactivity tended to decrease as patient age was higher in both types of asthma. Neither ventilatory function (FEV1.0%) nor the proportions of BAL lymphocytes and neutrophils was not correlated with bronchial hyperresponsiveness in both types of asthma. 4. Bronchial reactivity to methacholine more dereased with the increase in the proportion of BAL eosinophils in both type Ia-1 and Ia-2 asthma patients. The results show that bronchial hyperresponsiveness in patients with type Ia asthma is correlated to patients age and the proportion of BAL eosinophils.
Abstract Alternative 気管支喘息患者Ia型(単純気管支れん縮型)39人(Ia-1型25人,Ia-2型14人)の気道過敏性を年齢,呼吸機能検査,気管支肺胞洗浄液(BAL)中の細胞成分と関連で検討を行った。1.BAL液中の好酸球の比率はIa-1型に比べIa-2型で優位に高値であった。2.メサコリンに対しての過敏性はIa-1型とIa-2型とで差を認めなかった。3.気道過敏性はどちらの病型においても年齢にともなって減弱する傾向にあったが,一秒率及びBAL液中の好中球,リンパ球の比率とは相関しなかった。4.メサコリンに対しての気道過敏性はIa-1型,Ia-2型ともにBAL液中の好酸球の比率が増加するにしたがって亢進した。以上より単純気管支れん縮型(Ia型)の気管支喘息患者の気道過敏性はその年齢,BAL液中の好酸球の比率に相関することが示唆された。
Keywords Bronchial hyperresponsiveness Type Ia asthma Patient age BAL eosinophiIs
Publication Title 岡大三朝分院研究報告
Published Date 1996-11
Volume volume67
Start Page 28
End Page 34
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307134
Author Takata, Shingo| Mifune, Takashi| Mitsunobu, Fumihiro| Okamoto, Makoto| Nishida, Norikazu| Tsugeno, Hirofumi| Ashida, Kozo| Hosaki, Yasuhiro| Yokoi, Tadashi| Tanizaki, Yoshiro| Niiya, Kenji| Tanimoto, Mitsune|
Published Date 2003-02-01
Publication Title 岡大三朝医療センター研究報告
Volume volume73
Content Type Departmental Bulletin Paper
Author Nishida, Norikazu| Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Okamoto, Makoto| Nagata, Takuya| Yokoi, Tadashi| Nakai, Mutsuo| Makino, Hirofumi| Tanizaki, Yoshiro|
Published Date 2003-02-01
Publication Title 岡大三朝医療センター研究報告
Volume volume73
Content Type Departmental Bulletin Paper
JaLCDOI 10.18926/14953
Title Alternative 肺気腫患者におけるロイコトリエンB4,C4産生能と高分解能CTによる平均CT値との関連
FullText URL 069_015_020.pdf
Author Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Harada, Seishi| Yumoto, Eiichiro| Takata, Shingo| Ochi, Koji| Harada, Hideo| Hasegawa, Harumi|
Abstract The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by peripheral leukocytes stimulated with Ca ionophore A23187 was examined in 17 patients with pulmonary emphysema. They were divided into three groups according to the mean CT number; A (<-940 HU), B (-940 ≦, <-930 HU), and C (-930 HU ≦ ).1. The values of FVC (% predicted), FEV1.0% and DLco (% predicted) showed a tendency to decrease as the mean CT number was smaller. The value of % FVC was significantly lower in patients with group A than in those with group C (p<0.05). 2. The generation of both LTB4 and LTC4 was significantly higher in patients with emphysema compared to the generation in healthy subjects (LTB4;p<0.05, LTC4;P<0.05). 3. The generation of LTB4 and LTC4 in patients with emphysema was higher as the mean CT number was larger (severity of the disease become less). The LTC4 production was significantly higher in patients with group C(mild or moderate type of emphysema) than in those with group A(advanced type of emphysema). These results suggest that the generation of LTB4 and LTC4 is higher in patients with mild or moderate type of emphysema than in those with advanced type of the disease.
Abstract Alternative 肺気腫患者17名を対象として,カルシウムイオノフォアA23187による末梢血白血球からのロイコトリエンB4(LTB4), ロイコトリエンC4(LTC4)の産生能の検討を行った。対象は高分解能CTによる平均CT値によってA(<940HU), B(-940≦,<-930HU),C(-930HU≦)の3群に分類した。1.% FVC,FEV1.0%,% DLcoが低下するにつれて平均CT値が低下する傾向が見られた。% FVC値はC群に比較して,A群において有意に低値を示した(p<0.05)。2.LTB4とLTC4の産生能は健常人に比較して,肺気腫患者において有意に高値を示した(LTB4;p<0.05,LTC4;p<0.05)。3.肺気腫患者におけるLTB4とLTC4の産生能は平均CT値が上昇するにつれて(軽症症例ほど)高値を示した。またLTC4産生能はC群(早期肺気腫症例)においてA群(進行肺気腫症例)に比して有意に高値を示した。以上より肺気腫におけるLTB4,LTC4産生能は進行例に比較すると,軽・中等症例において高値であることが示唆された。
Keywords emphysema mean CT number LTB4 LTC4
Publication Title 岡大三朝分院研究報告
Published Date 1998-12
Volume volume69
Start Page 15
End Page 20
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308094
Author Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Nishida, Norikazu| Nagata, Takuya| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro|
Published Date 2003-02-01
Publication Title 岡大三朝医療センター研究報告
Volume volume73
Content Type Departmental Bulletin Paper
Author Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Nishida, Norikazu| Nagata, Takuya| Yokoi, Tadashi| Takata, Shingo| Tanizaki, Yoshiro|
Published Date 2003-02-01
Publication Title 岡大三朝医療センター研究報告
Volume volume73
Content Type Departmental Bulletin Paper
JaLCDOI 10.18926/15008
Title Alternative 中高年発症型喘息患者におけるIgE系アレルギー反応の加令による変化
FullText URL 067_050_056.pdf
Author Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo|
Abstract Age-related changes in IgE-mediated allergic reaction were examined in patients with late onset asthma, whose asthma occured over the age at onset of 40. 1. The number of patients with a high serum IgE level over 3001U/mℓ was larger in those between the ages at onset of 40 and 49 and over age at onset 60 than in those between the ages at onset 50 and 59. 2. A positive RAST score to Hdm and cockroach allergens was more frequently found in patients between 40 and 49 and over age 60 at onset compared to those between 50 and 59 at onset. In contrast, the number of patients with a positive RAST to Candida was larger in those between 50 and 59 at onset than in those of between 40 and 49 and over 60 at onset. 3. Severe asthma was more frequently and slight asthma was less frequently observed in patients between 50 and 59 at onset than in those of the other age at onset groups. These results suggest that IgE-mediated allergic reaction in patients between the ages at onset of 50 and 59 is different from that in those with early onset asthma, and that the reaction in patients between the ages at onset 40 and 49 and over 60 resembles to the reaction in those with early onset asthma.
Abstract Alternative 発症年令が40才以上の中高年発症型喘息患者におけるIgE系アレルギー反応の加令による変化について検討を加えた。1.発症年令が40から49才と60才以上の患者では,50から59才の患者に比して血清IgE値が300IU/mℓ以上の高値を示す頻度が高い傾向が見られた。2.ダニ,ゴキブリに対するRAST陽性率は発症年令が50から59才の患者に比して,40から49才と60才以上の患者で高値を示した。一方,カンジダに対するRAST陽性率は,発症年令が40から49才と60才以上の患者に比して,50から59才の患者で高値を示した。3.発症年令が50から59才の患者では,他の発症年令の患者に比べて,重症例が多く,軽症例が少ない傾向が見られた。以上の結果から,発症年令が50から59才の患者のIgE系アレルギー反応は若年発症型喘息患者と異なり,発症年令が40から49才と60才以上の患者のIgE系アレルギー反応は若年発症型喘息患者と 類似することが示唆された。
Keywords IgE RAST 吸入抗原 (inhalant Allergen) 気管支喘息 (Bronchial asthma) 加令 (aging)
Publication Title 岡大三朝分院研究報告
Published Date 1996-11
Volume volume67
Start Page 50
End Page 56
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307989