Author Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Takata, Shingo| Kikuchi, Hiroshi| Hamada, Masanori|
Published Date 2008-03-01
Publication Title 岡大三朝医療センター研究報告
Volume volume76
Content Type Departmental Bulletin Paper
Author Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Hamada, Masanori| Iwagaki, Naofumi| Fujii, Makoto| Takata, Shingo|
Published Date 2004-12-01
Publication Title 岡大三朝医療センター研究報告
Volume volume75
Content Type Departmental Bulletin Paper
Author Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Nishida, Norikazu| Tsugeno, Hirofumi| Nagata, Takuya| Yokoi, Tadashi| Takata, Shingo|
Published Date 2003-02-01
Publication Title 岡大三朝医療センター研究報告
Volume volume73
Content Type Departmental Bulletin Paper
Author Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori|
Published Date 2004-02-01
Publication Title 岡大三朝医療センター研究報告
Volume volume74
Content Type Departmental Bulletin Paper
JaLCDOI 10.18926/14822
Title Alternative Spa therapy for patients with respiratory disease. Analysis of 1934 patients admitted at Misasa Medical Branch for last 20 years from 1982 to 2001
FullText URL 72_001_008.pdf
Author Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi|
Abstract 1982年1月より2001年12月までの20年間に当院へ入院した呼吸器疾患患者1934例のうち閉塞性換気障害を示す肺疾患1641例(気管支喘息BA+慢性閉塞性呼吸器疾患COPD)を対象に,5年間ごとに年齢,地域分布などの経年変化について検討を加えた。  1.最近20年間に当院へ入院した閉塞性換気障害を示す呼吸器疾患1641例のうち,気管支喘息は1226例(74.7%)であった。閉塞性呼吸器疾患のなかで気管支喘息の占める割合は,最初の5年間では106例中 57例(53.8%),1987年からの5年間では71.7% (271/378),1992年からの5年間では73.6% (433/588)で,最近の5年間では53.9% (465/862)と最近ではその割合がやや低下する傾向が見られた。  2.全ての気管支喘息のなかでステロイド依存性重症難治性喘息(SDIA)の割合は,最初の5年間をのぞけばほぼ横ばいで最近の5年間では35.3%であった。COPDのなかでの肺気腫の割合は,近年増加の傾向を示し,最初の5年間の4.7% (5/106)に対して最近の5年間では20.2% (174/862)であった。  3.年齢別検討では,閉塞性換気障害を示す全ての症例のうち60才以上の症例の割合は,最初の5年間では30.1%であったが,その後増加の傾向を示し,最近の5年間では68.0%であった。  4.地域分布では,鳥取県内からの入院患者に比べ,遠隔地(鳥取県外)からの入院患者が比較的多く,この20年間の鳥取県外(遠隔地)からの入院患者は1641例中853例(52.0%)であった。また,岡山,大阪,広 島,兵庫,東京,愛媛,山口,京都などからの入院症例が多い傾向が見られた。なお,入院患者の出身県は,35都道府県に及んでいた。
Abstract Alternative Analysis of 1934 patients with respiratory disease admitted at Misasa Medical Branch for last 20 years from 1982 to 2001 was performed every 5 years. Of al patients with respiratory disease, 1641 patients had asthma and chronic obstructive pulmonary disease (COPD). 1. Of 1641 patients showing obstructive ventilatory dy sfuncion, 1226 (74.7%) patients fad asthma. The frequency of asthma in all patients with respiratory disease was 53. 8% for the first 5 years from 1982, 71. 7% (271/378) for the second five years, 73.6% (433/588) for'The third 5 years from 1992, and 53.9% (465/862) for the last five years from 1997. 2. The frequency of steroid-dependent intractable asthma (SDIA) was from 29. 0% to 41. 3% except the frequency (68.4%) for the first 5 years. The frequency of pulmonary emphysema in those with COPD was very low (4.7%;5/106) for the first 5 years and the frequency (20.2%;174/862, for the last 5 years) tended to increase. The frequency of patients over age 60 was 30.1% for the first 5 years, and showed a tendency to increase, and 68.0% for the last 5 years. 3. The frequency of patients from distant areas outside Totton prefecture was larger compared to the frequency inside Totton prefecture (853/1641;52.0%). The number of patients from Okayama, Osaka, Hyogo, Tokyo, Ehime, Yamaguchi, and Kyoto was larger than the number from other distant areas.
Keywords 気管支喘息 (asthma) 肺気腫 (pulmonary emphysema) 温泉療法 (Spa therapy) 高齢患者 (aged patients) 遠隔地 (distant area)
Publication Title 岡大三朝分院研究報告
Published Date 2002-02-01
Volume volume72
Start Page 1
End Page 8
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002308041
JaLCDOI 10.18926/14903
Title Alternative Spa therapy for 999 patients with respiratory disease admitted at Misasa Medical Branch for last 7 years
FullText URL 071_001_009.pdf
Author Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Takata, Shingo| Ochi, Koji|
Abstract 1993年1月より1999年12月までの7年間に当院へ入院した呼吸器疾患999例のうち閉塞性換気障害を示す829例(気管支慌息BA+COPD)を対象に,年齢,地域分布などの経年変化について検討を加えた。 1.最近7年間に当院へ入院した閉塞性呼吸器疾患患者829例のうち, 気管支喘息は636例(76.7% )であった。閉塞性呼吸器疾患のなかで気管支喘息の占める割合の経年変化では,1996年度が最も高く(84.5% )その後徐々に低下する傾向か見られ1999年度では65.5% であった。一方′肺気腫は近年増加の傾向を示し,19993年度では5.6% であったが.1999年度では25.6% であった。  2.入院患者の地域分布では,鳥取県内からの入院患者に比べ,遠隔地(鳥取県外)からの入院患者が比較的多く,この7年間の鳥取県外(遠隔地)からの入院患者は829例中433例(52.2% )であった。また,岡山,大阪,兵庫,広島,山口,愛媛,東京,神奈川などからの入院症例か多い傾向が見られた。  3.年齢別検討では,いずれの地域においても,高齢者の入院症例が多く,鳥取県内,県外を問わず,70才以上の症例の頻度が明らかに高い傾向か見られた.そして,50才以上の症例の全症例に対する頻度は,鳥取県内では80.9% ,県外では96.7% であり,県内ではその多くが,また県外ではそのほとんどが50才以上の症例であった。
Abstract Alternative The patients with asthma or COPD who were admitted at our hospital for last 7 years (1993-1999) were examined in relation to patient age and areas where patients came. 1. Of 829 patients with obstructive ventilatory dysfunction, 636 patients (76.7% ) had asthma. The frequency of asthma in all patients with obstructive ventilatory dysfunction was the highest (84.5% ) in 1993 and showed a tendency to decrease to 65.5% in 1999. In contrast, the frequency ofpulmonary emphysema tended to increase from 5.6% in 1993 to 25.6% in 1999. 2. The number of patients with asthma or COPD from distant areas (outside Tottori prefecture) was larger (433 patients; 52.2% ) than the number of those inside Tottori prefecture (396 patients) for 7 years. The number of patients from Okayama, Osaka, Hyogo, Hiroshima, Yamaguchi, Ehime, Tokyo, and Kanagawa was. larger than the number from other distant areas. 3 . Regarding the distribution of age of these patients, the number of patients over the age of 50 in all subjects was larger in patients from distant areas (96.7% ) than in those inside Tottori prefecture (80.9% )
Keywords 気管支喘息 (asthma) 肺気腫 (pulmonary emphysema) 温泉療法 (Spa therapy) 高齢患者 (aged patients) 遠隔地 (distant area)
Publication Title 岡大三朝分院研究報告
Published Date 2001-02-01
Volume volume71
Start Page 1
End Page 9
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002308210
Author Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Hamada, Masanori| Yamaoka, Kiyonori| Tanizaki, Yoshiro|
Published Date 2004-12-01
Publication Title 岡大三朝医療センター研究報告
Volume volume75
Content Type Departmental Bulletin Paper
Author Hosaki, Yasuhiro| Mitsunobu, Fumihiro| Ashida, Kozo| Tsugeno, Hirofumi| Nishida, Norikazu| Nagata, Takuya| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro| Ochi, Koji| Fukuda, Tetsuya| Shiratori, Yasushi|
Published Date 2003-02-01
Publication Title 岡大三朝医療センター研究報告
Volume volume73
Content Type Departmental Bulletin Paper
JaLCDOI 10.18926/14978
Title Alternative Effect of spa therapy on peak expiratory flow in patients with bronchial asthma
FullText URL 068_028_033.pdf
Author Mifune, Takashi| Yamamoto, Kazuhiko| Iwagaki, Naofumi| Okamoto, Makoto| Tsugeno, Hirofumi| Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tanizaki, Yoshiro| Tada, Shinya| Harada, Mine|
Abstract 気管支喘息に対する温泉療法の効果をピークフローメーターを用いて継時的(第1週,第5過,第9週)に検討した。1.軽症・中等症では,第5週で有意にピークフロー (PEF)値は上昇した.重症気管支喘息例では第9週に有意な改善を認めた。2.20%以上のPEF値の改善を認めた症例の割合は第5週では,軽症・中等症・重症群で40~50%であったが,第9週では軽症群で80%,重症群で54.5%に増加していた。中等症群では第5週と同等であった。3.第1週のPEFが200(L/m)以下の症例では第5週,第9過とPEFの有意な改善を示したが,200<PEF≦300の症例,300<PEFの症例では有意な改善は認められなかった。4.PEF≦200(L/m)の症例群において,20%以上のPEFの改善を示す症例は,第5週で57%,第9週で69%と高率であった。200<PEF≦300の症群,300PEFの症例群では第9週で40%以上の症例が20%以上のPEFの改善を示した。
Abstract Alternative The aim of this study was to investigate effects of spa therapy on peak expiratory flow (PEF) in patients with bronchial asthma. Morning PEF metry was studied in fifty asthmatics who had spa therapy (swimming training in a hot spring pool, inhalation of iodine salt solution and fango therapy) for 5 - 9 weeks. Mean values of morning PEF at the initial stage, 5 and 9 weeks after spa therapy were assessed. In mild and moderate asthmatics, PEF significantly improved 5 weeks after spa therapy. In severe asthmatics, PEF showed significant increase 9 week. The number of subjects with PEF improvement more over 20%, compared with the intial value of PEF, were 50% at 5 weeks and 80% at 9 weeks after spa therapy in mild asthmatics. In moderate asthmatics, however, the number little changed between 5 (39.3%) and 9 weeks (38.9%) after the therapy. In severe asthmatics, 57.1% at 5 and 68.8% at 9 weeks. In asthmatics with the initial value of PEF<200L/m (low PEF group), the value showed significant increase 5 and 9 weeks after the therapy compared with the initial value. In asthmatics with the initial values of 200≦PEF<300 (middle PEF group) and 300≦PEF (high PEF group), the values showed no significant increase. The number of subjects with PEF improvement more than 20% showed a tendency to increase 9 weeks in low, middle and high PEF group, compared to the value after spa therapy (57.1% to 68.8%, 21.4% to 50% and 35.7% to 42.9%, respectively ).
Keywords bronchial asthma spa therapy peak expiratory flow (PEF)
Publication Title 岡大三朝分院研究報告
Published Date 1997-12
Volume volume68
Start Page 28
End Page 33
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002308119
Author Takata, Shingo| Ashida, Kozo| Hosaki, Yasuhiro| Hamada, Masanori| Iwagaki, Naofumi| Kikuchi, Hiroshi| Mitsunobu, Fumihiro|
Published Date 2008-03-01
Publication Title 岡大三朝医療センター研究報告
Volume volume76
Content Type Departmental Bulletin Paper
JaLCDOI 10.18926/14964
Title Alternative The effects of perilla seed oil ointment for atopic dermatitis
FullText URL 069_076_081.pdf
Author Miyamoto, Miyuki| Akiyama, Chiaki| Noumi, Michiyo| Takata, Junko| Nisimura, Nobuko| Nakamura, Sumie| Kawakami, Yasuhiro| Okamoto, Makoto| Ashida, Kozo| Mitsunobu, Fumihiro| Tanizaki, Yoshiro|
Abstract 近年アトピー性皮膚炎が増加しており,工ゴマ油を使った食事療法がアレルギー抑制に有用であることが報告されている。そこで今回,エゴマ油を外用剤として使用するため,亜鉛華単軟膏を基剤とした工コマ軟膏を作製し,アトピー性皮膚炎患者3例を対象にその臨床応用を試みた。その結果,掻痒感の軽減に効果がみられ,また皮膚症状では,丘疹.表皮剥離,苔癬化,落屑などの所見が改善される傾向が見られた。
Abstract Alternative The perilla seed oil contains rich α-linolenic acid (α-LNA), parent n-3 fatty acid. The dietary intake of n-3 fatty acid, such as perilla seed oil, has been reported to have some clinical effects in patients with allergic disease. In this report, we prepared the perilla seed oil ointment for atopic dermatitis and the effects of the ointment was evaluated in three patients with atopic dermatitis. This ointment suppressed skin itch, and improved papules, excoriation, lichenification and desquamation of the skin. These results suggest that the perilla seed oil ointment has some effectiveness including suppression of inflammatory changes of the skin in patients with atopic dermatitis.
Keywords アトピー性皮膚炎 エゴマ軟膏 掻痒感
Publication Title 岡大三朝分院研究報告
Published Date 1998-12
Volume volume69
Start Page 76
End Page 81
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002308418
JaLCDOI 10.18926/14993
Title Alternative Diet therapy with α-linolenic acid-enriched perilla seed oil on pulmonary emphysema.
FullText URL 068_099_106.pdf
Author Tsugeno, Hirofumi| Ashida, Kozo| Mitsunobu, Fumihiro| Mifune, Takashi| Okamoto, Makoto| Iwagaki, Naofumi| Hosaki, Yasuhiro| Tsuji, Takao| Tanizaki, Yoshiro|
Abstract 症例は67歳,男性。主訴は労作時呼吸困難。【第一回目入院】平成7年9月から12月まで入院し,薬物療法,複合温泉療法を行なった。自覚症状はやや改善がみられたが,呼吸機能検査所見の改善は得られなかった。【第二回目入院】平成8年8月から12月まで入院。n-3系脂肪酸強化食事療法も併用した。自覚症状および,呼吸機能検査上,FVC,FEV(1.0),PEFなどに改善を認めた。n-3系脂肪酸はアラキドン酸代謝を通してロイコトリエン合成に関与すると推定されるが,経過中に白血球のLTB(4)産生能の減少を認めた。この症例は肺気腫に対するn-3系脂肪酸強化食事療法の有用性が示唆され,病態を考える上でも興味深いと考えられたので報告する。
Abstract Alternative An effective treatment of advanced stages of chronic obstructive pulmonary disease (COPD) has not been estadlished yet. We report out recent experience of one patient with pulmonary emphysema treated with dietary supplementation with n-3 fatty acid for two months. He presented improvements in clinical symptoms and pulmonary function, and suppression in generation of leukotriene B(4) (LTB(4) )by peripheral leukocytes. Weconsequently suppose that dietary treatment with n-3 fatty acids (perilla seed oil) may be beneficial for the treatment of pulmonary emphysema by inhibiting the conversion of arachidonic acid (AA) to leukotrienes (LTs) and prostanoids competitively.
Keywords 肺気腫 (pulmonary emphysema) n-3系脂肪酸 (n-3 fatty acid) 食事療法 (diet therapy) ロイコトリエン合成 (leukotriene)
Publication Title 岡大三朝分院研究報告
Published Date 1997-12
Volume volume68
Start Page 99
End Page 106
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002308310
Author Mitsunobu, Fumihiro| Ashida, Kozo| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Nagata, Takuya| Takata, Shingo| Tanizaki, Yoshiro|
Published Date 2003-02-01
Publication Title 岡大三朝医療センター研究報告
Volume volume73
Content Type Departmental Bulletin Paper
JaLCDOI 10.18926/15091
Title Alternative Ⅱ型喘息(細気管支閉塞型)と気管支肺胞洗浄液の好中球数
FullText URL 067_079_084.pdf
Author Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa|
Abstract Bronchial asthma is classified into three types ; type Ia (Ia-1 and Ia-2), type Ib, and type Ⅱ, by clinical symptoms (clinical diagnosis). Asthma is also classified by clinical findings and examinations (score diagnosis). Both classification systems show that markedly increased proportion of BAL neutrophils and marked decrease in % V25 value are characteristic of type Ⅱ, bronchiolar obstruction, asthma. However, there are some type Ⅱ asthma patients without BAL neutrophilia. In these patients, age is higher compared to those with BAL enutrophlia. Decrease in FEV1.0% value and decrease in the proportion of BAL lympocytes and serum IgG level, are not so remarkable as decrease in those with BAL neutrophilia. It has been suggested that type Ⅱ asthma with BAL neutrophilia correlates with suppression of humoral and cellular immunity, and same type of astma without BAL neutrophilia is in part caused by aging.
Abstract Alternative 気管支喘息は,その臨床症状より,Ia型(Ia-1およびIa-2),Ib型およびⅡ型の3つの病型に分けることができる(臨床分類)。また,同時に臨床所見および検査により分類することができる(スコアー分類)。いずれの分類においても,BAL液中の好中球の著増および高度な% V25値の低下がⅡ細気管支閉塞型の特徴的所見である。しかしながら,BAL液中の好中球の増加をともなわないⅡ型喘息が存在することが明らかにされている。これらの症例では,BAL液 中好中球増加をともなう症例に比べ平均年齢が高い。しかし,FEVl.0% 値、BAL液中リンパ球頻度や血清IgG値などは、好中球増加をともなう症例ほどの低下傾向は見られない。これらの結果はBAL液中好中球増加をともなうⅡ型z喘息の発症機序には、液性および細胞性免疫能の低下が、また、BAL液中好中球増加をともなわないⅡ型喘息では、加齢がある程度関連していることを示 している。
Keywords Asthma classification (喘息分類) BAL lymphocytes (BALリンパ球) BAL neutrophils (BAL好中球) % V25 value Ⅱ型喘息
Publication Title 岡大三朝分院研究報告
Published Date 1996-11
Volume volume67
Start Page 79
End Page 84
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307924
JaLCDOI 10.18926/14836
Title Alternative 高齢者気管支喘息の臨床病態におけるロイコトリエンB4,C4の役割. 気道過敏性とFEV1.0%との関連
FullText URL 72_023_030.pdf
Author Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro|
Abstract The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes stimulated with Ca ionophore A23187 was examined in 67 patients with asthma. 1. The generation of leukotriene B4 (LTB4) by leucocytes was significantly more increased in patients with asthma than in those with pulmonary emphysema (PE) and healthy subjects. The generation of leukotriene C4 (LTC4) was also signficantly more increased in patients with asthma compared to the generation in those with PE and healthy subjects. The generation of both LTB4 and LTC4 was significantly more increased in patients with PE than in healthy subjects. 2. The generation of both LTB4 and LTC4 was larger in patients with asthma over age 70 than in those of other age groups, however, the difference was not significant. 3. The generation of LTC4 was significantly higher in attack stage than in non-attack stage in all age groups of patients with asthma, however, the generation of LTB4 was not significantly different between the two stages. 4. Bronchial hyperresponsiveness to methacholine in patients with asthma tended to decrease with aging, and the bronchial hyperresponsiveness was to a certain extent correlated with the generation of LTB4, but not LTC4. 5. The generation of LTC4 was correlated with value of FEV1.0%. These results may suggest that both LTB4 and LTC4 participate in the pathophysiology of asthma in the elderly.
Abstract Alternative 気管支喘息67例を対象に, Ca ionophoreA23187刺激時の白血球からのロイコトリエンB4(LTB4)およびC4 (LTC4)の産生を観察し,高齢者喘息の臨床病態におけるLTB4,LTC4の役割について検討した。  1.LTB4の産生は,気管支喘息において肺気腫および健康人に比べ有意に高い値を示した。LTC4の産生も同様に気管支喘息において,肺気腫,健康人に比べ有意に高い値30を示した。LTB4,LTC4いずれの産生も,肺気腫症例において健康人と比べ有意に高い値が観察された。  2.LTB4,LTC4の産生は,70才以上の喘息症例において,他の年齢層の症例に比べより高い値が示されたが,推計学的な有意差は見られなかった。  3.高齢者を含めいずれの年齢層の気管支喘息においても,LTC4の産生は発作時に,非発作時に比べ有意の亢進が見られたが,LTB4に関しては発作時,非発作時の間に有意の差は見られなかった。  4.気道の過敏性は,年齢が高くなるにつれて低下する傾向が見られた。そして,この気道の過敏性はLTB4産生とある程度関連していることが示されたが,LTC4との関連は見られなかった。  5.FEV1.0%値は,ある程度LTC4産生亢進と関連があることが示された。 以上の結果より,70才以上の喘息においても,LTB4,LTC4がその発作時病態に重要な役割を果していることが示唆された。
Keywords asthma LTB4 LTC4 FEV1.0% bronchial hyperresponsiveness
Publication Title 岡大三朝分院研究報告
Published Date 2002-02-01
Volume volume72
Start Page 23
End Page 30
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308466
JaLCDOI 10.18926/14838
FullText URL 72_038_044.pdf
Author Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro|
Abstract Changes in the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes after spa therapy were examined in 30 patients with asthma. 1. The efficacy of spa therapy was marked in 8 (26.7%), and moderate in 16 (53.3%) of 30 patients with asthma, and slight or no efficacy of the therapy was observed in the residual 6 patients (20.0%). 2. Bronchial reactivity to methacholine was the highest in patients with slight or no efficacy of spa therapy, however. there were no significant differences among the three groups classified by clinical efficacy. 3. The generation of LTC4 was significantly higher in patients with slight or no efficacy compared with the generation in those with marked (p<O. 01) and moderate efficacy (p<O. 001). However, there were no signifcant differences in the generation of LTB4 among them. 4. The generation of LTC4 signifcantly decreased in patients with marked and moderate efficacy after spa therapy. but not in those with slight or no efficacy. The generation of LTB4 was not significantly different before and after spa therapy among patients with marked, moderate, and slight or no efficacy. These results show that the efficacy of spa therapy for patients with asthma is closely related to the generation of LTC4 by leucocytes.
Abstract Alternative 気管支喘息30例を対象に,温泉療法によるロイコトリエンB4 (LTB4),C4 (LTC4)産生の変動および気道過敏性と臨床効果との関連について検討を加えた。  1.温泉療法の臨床効果は,著効8例(26.7%),有効16例(53.3%),やや有 効あるいは無効6例(20.0%)であった。  2.メサコリンに対する気道過敏性は,やや有効あるいは無効例で高い傾向が見られたが,著効,有効例と比べ有意の差は見られなかった。 3.LTC4産生はやや有効あるいは無効例において著効例(P<0.01)や有効例(P<0.001)に比べ有意に高い値が示された。しかし,LTB4産生では臨床効果との関連は見られなかった。  4.著効例および有効例では,温泉療法後にLTB4産生の有意の低下 傾向が見られたが,無効例では有意の変動は見られなかった.また,LTB4産生に関しては温泉療法の臨床効果にかかわらず有意の変動は見られなかった。これらの結果より,気管支喘息に対する温泉療法の臨床効果は,LTC4産生とある程度関連していることを示唆しているものと考えられる。
Keywords asthma spa therapy bronchial hyperresponsiveness LTB4 LTC4
Publication Title 岡大三朝分院研究報告
Published Date 2002-02-01
Volume volume72
Start Page 38
End Page 44
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308539
JaLCDOI 10.18926/14959
Title Alternative n-3系脂肪酸食の気管支喘息に対する臨床効果:n-6系脂肪酸との比較
FullText URL 069_040_048.pdf
Author Okamoto, Makoto| Ashida, Kozo| Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Harada, Seishi| Yumoto, Eiichiro| Takata, Shingo| Tanizaki, Yoshiro| Kataoka, Mikio| Harada, Mine|
Abstract N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma by suppressing leukocyte function, followed by reduction of the need for pharmacologic agents. To examine the effects of dietary supplementation with perilla seed oil rich in α-linolenic acid (ALA), 23 patients with asthma took corn oil rich in linoleic acid (LA) for the former two weeks, perilla seed oil for the later two weeks. The asthmatic patients were classified into two groups by the changes of the generation of leukotrienes B4 (LTB4), C4 (LTC4), and B5 (LTB5) during the two courses of dietary modification: one was sensitive to dietary modification, and the other was insensitive to dietary supplementation. We compared the two groups in clinical characteristics. Significant differences were observed in peak flow (PEF), forced expiratory volume in one second (FEV1.0), IgE, sex, obesity index (OI), concentration of serum total cholesterol, albumin, low density lipoprotein {LDL)-cholesterol, β-lipoprotein and phospholipids between two groups. This study indicated that these factors influence the generation of LTB4, C4 and B5 of asthmatic patients in dietary supplementation.
Abstract Alternative 気道への炎症性白血球の集合が気管支喘息の病態に関わっている。魚油などのn-3系脂肪酸が白血球の機能を抑制することにより気管支喘息患者に良好な効果をもたらし,薬剤の必要性を減じたとの報告がなされている。α-リレノン酸を豊富に含有するエゴマ油食の効果を調べるため,気管支喘息患者23名に2コースの食事-リノール酸の豊富なコーン油食を2週間摂取後,エゴマ油食を2週間-を摂取してもらった。喘息患者は2コースの食事間のロイコトリエンB4(LTB4),CA(LTC4),B5(LTB5)の変化から2群-1群は食事に対し感受性のある群,もう1つは感受性の無い群-に分類した。我々はこの2群を臨床的に検討したところ,ピークフロー(PEF),1秒量(FEV10),IgE,性別,肥満率(OⅠ),血清総コレステロール,アルブミン,低比重リポ蛋白(LDL)-コレステロール,β-リポ蛋白,リン脂質において2群間に有意差が認められた。今回の研究から,これらの因子が,喘息患者において,LTB4,LTC4,LTB5の産生に対する食事療法の効果に影響を及ぼしていることが示唆された。
Keywords n-3系脂肪酸 (n-3 fatty acids) エゴマ油 (perilla seed oil) 気管支喘息 (bronchial asthma) LTB4 LTC4
Publication Title 岡大三朝分院研究報告
Published Date 1998-12
Volume volume69
Start Page 40
End Page 48
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308199
JaLCDOI 10.18926/14904
Title Alternative 高齢者気管支喘息における気道過敏性と温泉療法
FullText URL 071_010_018.pdf
Author Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Takata, Shingo| Ochi, Koji|
Abstract Clinical effects of spa therapy were examined in 150 patients with asthma in relation tobronchial hyperresponsiveness and patient age. 1. The efficacy rate of spa therapy was larger as the patient age was higher: the rate was 73.3% in patients under age 49, 81.8% in those between the ages of 50 and 59, 86.4% in those between the ages of 60 and 69, and 90.6% in those over age 70. The mean of efficacy rates was 83.3% in all subjects. 2. The bronchial hyperresponsiveness (BH) was lower as patient age was higher: the BH in patients between the ages of 60 and 69 and in those over age 70 was significantly lower compared to the BH in those under age 49 (p < O.OOl). 3. Clinical effects of spa therapy tended to be lower in patients with increased bronchial hyperresponsiveness. The bronchial hyperresponsiveness showed a tendency to decrease after spa therapy in whom the therapy was effective, however, the BH did not change in patients with slight or no efficacy during spa therapy.
Abstract Alternative 1.温泉療法では,年齢が高くなるほどその有効率も高くなると言う傾向が見られ、49才以下の症例では73.3% ,50-59才の症例では81.8% , 60-69才の症例では86.4% ,70才以上では90.6% であり,全症例の平均有効率は73.3% であった。  2.気道過敏性は,年齢が高くなるほど低下する傾向が見られ,60-69才および70才以上の症例の気道過敏性は,49才以下の症例と比べ有 意に低い値を示した(P < 0.001)。  3.温泉療法の臨床効果は,気道過敏性が強くなるにつれて低下する傾向が見られた。また,温泉療法の著効例や有効例では,治療により 気道過敏性が低下してくるが、やや有効例や無効例では,気道過敏性はほとんど変化しないことが示された。
Keywords spa therapy asthma bronchial hyperresponsiveness patient age
Publication Title 岡大三朝分院研究報告
Published Date 2001-02-01
Volume volume71
Start Page 10
End Page 18
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308660
Author Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Fujii, Makoto| Takata, Shingo| Hamada, Masanori| Tanizaki, Yoshiro|
Published Date 2004-12-01
Publication Title 岡大三朝医療センター研究報告
Volume volume75
Content Type Departmental Bulletin Paper
JaLCDOI 10.18926/14926
Title Alternative 気管支喘息症例における気道過敏性と鼻腔・副鼻腔疾患の関係に関する検討
FullText URL 070_028_035.pdf
Author Mifune, Takashi| Takata, Shingo| Okamoto, Makoto| Tsugeno, Hirofumi| Ashida, Kozo| Harada, Seishi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tanizaki, Yoshiro| Harada, Mine|
Abstract Pathological changes of nasosinus occur often in subjects with bronchial asthma. Coexisting nasosinus lesion may affect pathophysiology of lower respiratory tract in asthmatics. The extent of nasal and sinus lesion was quantified in 17 patients with bronchial asthma, and their relationships to atopic status, asthma severity and bronchial hyperresponsiveness were evaluated in this study. Opacification degree of maxillary sinuses and nasal mucosa thickening were quantified using CT scans. The opacification degree was evaluated as (total opacification area)/(total maxillary sinus area). Although the opacification degree of maxillary sinuses in atopic patients showed no significant difference compared with that in non-atopic patients, maximum nasal mucosa thickening in atopic patients had a significant difference compared with that in non-atopic patients (p=0.028). In severe asthmatics, the opacification degree of maxillary sinuses was significantly more prominent compared with those in moderate and mild asthmatics (p=0.0005, p=0.036, respectively). Significantly marked nasal mucosa thickening was recognized in mild asthmatics compared with that in moderate asthmatics (p=0.0462). Regarding bronchial hyperresponsiveness, a significant correlation between Dmin and the opacification degree of maxillary sinuses was observed (rs= -0.551, p=0.0276). Nasal mucosa thickening had no correlation with bronchial hyperresponsiveness. The results suggest that sinusitis may affect bronchial hyperresponsiveness and asthma severity. Treatment of sinusitis may lead to improvement of asthma symptoms.
Abstract Alternative 鼻腔・副鼻腔疾患はしばしば気管支喘息症例に合併が認められ,喘息症例の下気道病態に影響を及ぼしている可能性が考えられる。今回,気管支喘息17例において,CTを用いて上顎洞の不透明化率・鼻腔粘膜肥厚を計測し,アトピー性の有無,喘息の重症度,気道過敏性との関係を検討した。上顎洞不透明化率は全上顎洞面積の総計に対する不透明化領域面積総計として計算を行った。上顎洞不透明化率はアトピー性の有無で差は認められなかったが,鼻腔粘膜はアトピー性喘息症例で有意に肥厚していた。重症気管支喘息における上顎 洞不透明化率は,中等症および軽症喘息症例に比べ有意に高値であった。鼻腔粘膜肥厚は中等症喘息症例に比べ,軽症症例で有意に肥厚していた。気道過敏性(Dmin)は上顎洞不透明化率とのあいだに弱い負の相関が認められた(rs=-0.551,p=0.0276).鼻粘膜肥厚と気道過敏性は相関が認められなかった。今回の結果から副鼻腔病変が気道過敏性・喘息重症度に影響を及ぼしている可能性が考えられ.副鼻腔疾患の治療により喘息症状の改善に繋がる可能性が考えられた。
Keywords 気管支喘息 (bronchial asthma) 副鼻腔炎 (sinusitis) CT所見 (CT findings) 気道過敏性 (hyperresponsiveness)
Publication Title 岡大三朝分院研究報告
Published Date 1999-12
Volume volume70
Start Page 28
End Page 35
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308098