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ID 57574
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Author
Wang, Yang Graduate School of Environmental and Life Science , Okayama University
Hatabu, Toshimitsu Graduate School of Environmental and Life Science , Okayama University Kaken ID researchmap
Abstract
This study aimed to evaluate the microbial compositions and gene expression related to inflammation in dextran sodium sulfate (DSS)-induced acute colitis and the effect of mulberry supplementation. Male BALB/c mice received a diet supplemented with mulberry juice freeze-dried powder (MFP) or not for 3 weeks. After 3 weeks, the mice received water containing 5% (w/v) DSS or not for 1 week. The disease activity index score in mice fed MFP was significantly decreased. A significant decrease in Bifidobacterium spp. and the Clostridium perfringens subgroup was observed in mice not fed MFP. The number of goblet cell and NLRP6 expression were observed in mice fed a diet supplemented with MFP compared with mice not fed MFP. These results may indicate that mulberry mitigates DSS-induced acute colitis by a changing the gut microbial flora and by improving mucosal conditions.
Keywords
DSS-induced acute colitis
Mulberry
NLRP6 inflammasome
goblet cell
microbiota
Note
This fulltext will be available in Feb 2020
Published Date
2019-02-17
Publication Title
Bioscience, Biotechnology and Biochemistry
Volume
volume83
Issue
issue5
Publisher
TAYLOR & FRANCIS
Start Page
914
End Page
922
ISSN
0916-8451
NCID
AA10824164
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
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DOI
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Related Url
isVersionOf https://doi.org/10.1080/09168451.2019.1580135