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ID 15124
Eprint ID
15124
FullText URL
Title Alternative
Evaluation of airway response to salbutamol sulfate and disodium cromoglycate in bronchial asthma by use of body pletysmograph
Author
Yokota, Satoshi
Mifune, Takashi
Kajimoto, Kazuhiro
Tanizaki, Yoshiro
Abstract
サルブタモール,クロモグリク酸ナトリウム(クロモリン)吸入液を,気管支喘息(以下BA)11例,肺病変のない対照群9例に吸入させ,吸入前および吸入後30分に,sRaw(specific airway resistance)とsGaw(specific airway conductance)を,定容積型体プレチスモグラフ(Sensor Medics Corporation, Anaheim, California, U.S.A.)を用いて測定した。サルブタモールの場合,BAでは吸入後に有意な改善(p<0.01)を認め,対照群でも有意な変化(p<0.05)があったが,改善率(%)はBA が対照群に比べて有意に高かった(p<0.01)。クロモリンの場合,吸入前後での比較では有意差は認めなかったが,吸入後にBAでは改善,対照群では悪化する傾向があり,改善率(%)はBA が対照群に比べて有意に高値(p<0.01)であった。
Abstract Alternative
We examined airway response to salbutamol sulfate and disodium cromoglycate (cromolyn) in 11 patients with bronchial asthma (BA), and 9 subjects of controls (no lung diseases), using a constant volume, whole body plethysmograph (Sensor Medics Corporation, Anaheim, California, U.S.A.). The results were expressed by specific airway resistance (sRaw) and specific airway conductance (sGaw), and compared before and 30 minuites after inhalation of agents. The sGaw and sRaw were significantly improved in BA (p<0.01) and in controls (p<0.05) after inhalation of salbutamol sulfate and the improvement rate after inhalation was significantly higher in BA than in controls (p<0.01). In case of cromolyn, there was no significant change of sGaw and sRaw in BA and controls after inhalation, but there was tendency of improvements of sGaw and sRaw in BA, and the improvement rate of these parameters after inhalation was significantly higher in BA than in controls (p<0.01).
Keywords
体プレチスモグラフ (body pletysmograph)
気管支喘息 (bronchial asthma)
サルブタモール (salbutamol)
クロモリン (disodium cromoglycate)
Published Date
1995-09
Publication Title
岡大三朝分院研究報告
Publication Title Alternative
Annual Reports of Misasa Medical Branch, Okayama University Medical School
Volume
volume66
Publisher
岡山大学医学部附属病院三朝分院
Publisher Alternative
Misasa Medical Branch, Okayama University Medical School
Start Page
49
End Page
56
ISSN
0918-7839
NCID
AN10430852
Content Type
Departmental Bulletin Paper
language
日本語
File Version
publisher
Refereed
False
Eprints Journal Name
mmc