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ID 40747
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Title Alternative
Effects of enflurane anesthesia on circulation dynamics and blood catecholamine concentration
Author
Kajiki, Hideki
Abstract
Effects of enflurane anesthesia were studied on the circulation dynamics and blood catecholamine (CA) concentrations during and after inhalation 2% or 3% enflurane in oxygen in 8 dogs at each concentration. During inhalation, the mean arterial pressure (MAP) and cardiac index (CI) decreased significantly. After stopping inhalation, the MAP recovered rapidly to the control values, but the CI recovered to only 65% of the control values. Immediately after starting inhalation, blood CA concentrations decreased significantly in both groups. After stopping inhalation, blood adrenaline (AD) concentration increased rapidly to 6 and 5 times as the control values in the 2% and 3% groups, respectively. Blood noradrenaline (NA) concentration increased to 3 times as the control values in both groups. One hundred and twenty min after starting inhalation, the dogs did not respond to painful stimulation even in the 2% group. In this study, it has been suggested that the circulation dynamics are suppresed when enflurane has reached more than 0.5 minimum alveolar concentration (MAC) and that the centripetal impulse is thoroughly blocked and CA secretion from the adrenal grand is inhabited at 0.7 MAC of enflurane.
Keywords
血中エンフルレン濃度
血中アドレナリン濃度
血中ノルアドレナリン濃度
循環動態
Published Date
1989-08-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume101
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
699
End Page
709
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/101/7-8/101_7-8_699/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma